LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Trametinib 56.36 12.8
0.0217
0.0212
 0.0706 0.0936 4.0713 0.3913
MCF 10A-H2B-mCherry Trametinib 58.33 12.8
0.0222
0.0223
 0.0302 0.0515 4.3444 0.4024
MCF 10A-H2B-mCherry Trametinib 60.30 12.8
0.0236
0.0232
 0.0787 0.0863 5.0000 0.3806
MCF 10A-H2B-mCherry Trametinib 62.27 12.8
0.0255
0.0246
 0.0151 0.0703 4.3386 0.3770
MCF 10A-H2B-mCherry Trametinib 68.68 11.8
0.0271
0.0263
 0.0288 0.0625 5.0000 0.3792
MCF 10A-H2B-mCherry Trametinib 66.21 12.8
0.0293
0.0275
 0.0599 0.1396 5.0000 0.3328
MCF 10A-H2B-mCherry Trametinib 70.65 11.8
0.0304
0.028
 0.0121 0.1724 5.0000 0.3478
MCF 10A-H2B-mCherry Neratinib 24.34 11.8
0.0284
0.0292
 -0.0594 0.0081 1.1327 0.5345
MCF 10A-H2B-mCherry Trametinib 64.24 12.8
0.0312
0.0294
 0.0440 0.1264 5.0000 0.3304
MCF 10A-H2B-mCherry Trametinib 72.62 11.8
0.0314
0.0301
 -0.0207 0.1090 5.0000 0.3790
MCF 10A-H2B-mCherry Neratinib 22.37 11.8
0.0309
0.0304
 -0.0400 0.0052 0.9627 0.5264
MCF 10A-H2B-mCherry Neratinib 20.40 11.8
0.0393
0.034
 0.0651 0.0625 0.9562 0.4912
MCF 10A-H2B-mCherry Neratinib 26.31 11.8
0.0294
0.0356
 -0.1394 -0.0698 0.9337 0.5476
MCF 10A-H2B-mCherry Neratinib 16.47 11.8
0.0475
0.0399
 0.1640 0.1862 2.9328 0.4268
MCF 10A-H2B-mCherry Neratinib 18.43 11.8
0.0448
0.0413
 0.1418 0.1300 2.9533 0.4580
MCF 10A-H2B-mCherry Neratinib 28.28 11.8
0.0367
0.0686
 -0.2186 -0.2457 0.8189 0.5478
MCF 10A-H2B-mCherry Neratinib 14.50 11.8
0.1014
0.0723
 0.1817 0.1723 1.2230 0.3790
MCF 10A-H2B-mCherry Palbociclib 14.50 11.8
0.1749
0.0968
 0.2268 0.3503 2.9383 0.3639
MCF 10A-H2B-mCherry Neratinib 30.24 11.8
0.0554
0.1098
 -0.2672 -0.3266 0.8666 0.5194
MCF 10A-H2B-mCherry Neratinib 32.22 11.8
0.0754
0.1236
 -0.2609 -0.2950 0.9825 0.4833
MCF 10A-H2B-mCherry Neratinib 34.19 11.8
0.0949
0.1275
 -0.2058 -0.2119 1.2093 0.4546
MCF 10A-H2B-mCherry Neratinib 36.16 11.8
0.1155
0.1569
 -0.2429 -0.2540 1.3144 0.4403
MCF 10A-H2B-mCherry Etoposide 46.00 11.8
0.1489
0.1733
 -0.0796 -0.0732 1.1118 0.4814
MCF 10A-H2B-mCherry Neratinib 40.10 11.8
0.1666
0.1751
 -0.2056 -0.0606 3.0455 0.3506
MCF 10A-H2B-mCherry Etoposide 51.92 11.8
0.1156
0.1784
 -0.2132 -0.1905 2.7864 0.5566