LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 86.41 | 11.8 | Inf | Inf | -0.5643 | -0.9298 | 0.3611 | 0.5327 |
| MCF 10A-H2B-mCherry | Alpelisib | 84.44 | 11.8 | Inf | Inf | -0.6603 | -0.9436 | 0.4167 | 0.5697 |
| MCF 10A-H2B-mCherry | Alpelisib | 82.47 | 11.8 | Inf | Inf | -0.7155 | -0.9323 | 0.4722 | 0.5723 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.50 | 11.8 | Inf | Inf | -0.7248 | -0.9024 | 0.5606 | 0.5652 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.53 | 11.8 | Inf | Inf | -0.5687 | -0.7801 | 0.5348 | 0.5215 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.56 | 11.8 | Inf | Inf | -0.3605 | -0.5430 | 0.4156 | 0.4223 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.59 | 11.8 | Inf | Inf | -0.2722 | -0.3540 | 0.4280 | 0.3853 |
| MCF 10A-H2B-mCherry | Trametinib | 74.59 | 11.8 | Inf | Inf | 0.0817 | 0.0886 | 2.5000 | 0.3756 |
| MCF 10A-H2B-mCherry | Trametinib | 76.56 | 11.8 | Inf | Inf | -0.0241 | 0.0501 | 2.5000 | 0.4135 |
| MCF 10A-H2B-mCherry | Trametinib | 78.53 | 11.8 | Inf | Inf | -0.0282 | 0.0198 | 2.5000 | 0.4461 |
| MCF 10A-H2B-mCherry | Trametinib | 80.50 | 11.8 | Inf | Inf | -0.0324 | 0.1443 | 2.5000 | 0.3980 |
| MCF 10A-H2B-mCherry | Trametinib | 82.47 | 11.8 | Inf | Inf | -0.0247 | 0.0349 | 2.5000 | 0.5380 |
| MCF 10A-H2B-mCherry | Trametinib | 84.44 | 11.8 | Inf | Inf | 0.0511 | 0.0738 | 2.5000 | 0.5285 |
| MCF 10A-H2B-mCherry | Trametinib | 86.41 | 11.8 | Inf | Inf | -0.0396 | 0.0266 | 2.5000 | 0.5563 |
| MCF 10A-H2B-mCherry | Trametinib | 88.39 | 11.8 | Inf | Inf | 0.0264 | 0.0453 | 2.5000 | 0.6297 |
| MCF 10A-H2B-mCherry | Alpelisib | 72.62 | 11.8 | Inf | Inf | 0.1179 | 0.2602 | 0.5184 | 0.2709 |
| MCF 10A-H2B-mCherry | Alpelisib | 70.65 | 11.8 | Inf | Inf | 0.4267 | 0.6197 | 0.6734 | 0.2143 |
| MCF 10A-H2B-mCherry | Alpelisib | 68.68 | 11.8 | Inf | Inf | 0.5890 | 0.7519 | 2.5000 | 0.1166 |
| MCF 10A-H2B-mCherry | Alpelisib | 66.21 | 12.8 | Inf | Inf | 0.7208 | 0.7208 | 0.0000 | 0.0599 |
| MCF 10A-H2B-mCherry | Alpelisib | 64.24 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0006 |
| MCF 10A-H2B-mCherry | Alpelisib | 62.27 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0396 |
| MCF 10A-H2B-mCherry | Alpelisib | 60.30 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0098 |
| MCF 10A-H2B-mCherry | Alpelisib | 58.33 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0079 |
| MCF 10A-H2B-mCherry | Alpelisib | 56.36 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | 0.0012 |
| MCF 10A-H2B-mCherry | Alpelisib | 53.89 | 11.8 | Inf | Inf | 0.9884 | 0.9884 | 0.0000 | 0.0083 |