LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 66.21 | 12.8 | Inf | Inf | 0.7208 | 0.7208 | 0.0000 | 0.0599 |
| MCF 10A-H2B-mCherry | Trametinib | 64.24 | 12.8 | 0.0312 | 0.0294 | 0.0440 | 0.1264 | 5.0000 | 0.3304 |
| MCF 10A-H2B-mCherry | Trametinib | 66.21 | 12.8 | 0.0293 | 0.0275 | 0.0599 | 0.1396 | 5.0000 | 0.3328 |
| MCF 10A-H2B-mCherry | Vorinostat | 58.33 | 12.8 | 3.121 | 3.2846 | -0.0803 | -0.0654 | 4.1663 | 0.2100 |
| MCF 10A-H2B-mCherry | Vorinostat | 60.30 | 12.8 | 3.0037 | 3.1465 | -0.0371 | -0.0795 | 3.9007 | 0.2301 |
| MCF 10A-H2B-mCherry | Dasatinib | 56.36 | 12.8 | 4.4755 | 5.1499 | -0.1439 | -0.2471 | 4.9992 | 0.1271 |
| MCF 10A-H2B-mCherry | Dasatinib | 58.33 | 12.8 | 4.7813 | 6.0034 | -0.2173 | -0.5391 | 5.0000 | 0.1370 |
| MCF 10A-H2B-mCherry | Dasatinib | 62.27 | 12.8 | 4.3975 | 5.6665 | -0.1761 | -0.4952 | 5.0000 | 0.1176 |
| MCF 10A-H2B-mCherry | Dasatinib | 64.24 | 12.8 | 7.076 | 8.823 | -0.3039 | -1.0000 | 5.0000 | 0.1184 |
| MCF 10A-H2B-mCherry | Etoposide | 58.33 | 12.8 | 0.08 | 1.0748 | -0.1876 | -0.5621 | 2.6279 | 0.5816 |
| MCF 10A-H2B-mCherry | Etoposide | 60.30 | 12.8 | Inf | Inf | -0.0882 | -0.1344 | 2.5000 | 0.6136 |
| MCF 10A-H2B-mCherry | Alpelisib | 62.27 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0396 |
| MCF 10A-H2B-mCherry | Etoposide | 64.24 | 12.8 | Inf | Inf | -0.1610 | -0.2439 | 2.5000 | 0.6044 |
| MCF 10A-H2B-mCherry | Neratinib | 60.30 | 12.8 | 0.3735 | 0.4891 | -0.4937 | -0.4609 | 2.3613 | 0.3388 |
| MCF 10A-H2B-mCherry | Neratinib | 62.27 | 12.8 | 0.3897 | 0.5562 | -0.5658 | -0.5865 | 2.1736 | 0.3542 |
| MCF 10A-H2B-mCherry | Neratinib | 66.21 | 12.8 | 0.4418 | 0.7084 | -0.7114 | -0.8082 | 3.1712 | 0.3995 |
| MCF 10A-H2B-mCherry | Palbociclib | 56.36 | 12.8 | 4.6212 | 2.9453 | 0.2561 | 0.2318 | 2.3448 | 0.1793 |
| MCF 10A-H2B-mCherry | Alpelisib | 56.36 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | 0.0012 |
| MCF 10A-H2B-mCherry | Palbociclib | 62.27 | 12.8 | Inf | Inf | 0.3703 | 0.3202 | 1.2436 | 0.0891 |
| MCF 10A-H2B-mCherry | Alpelisib | 58.33 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0079 |
| MCF 10A-H2B-mCherry | Palbociclib | 66.21 | 12.8 | Inf | Inf | 0.3784 | 0.3627 | 2.5000 | 0.0744 |
| MCF 10A-H2B-mCherry | Alpelisib | 60.30 | 12.8 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0098 |
| MCF 10A-H2B-mCherry | Taxol | 64.24 | 12.8 | 0.0006 | 0.001 | -0.2726 | -0.5948 | 3.1044 | 0.9994 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.59 | 11.8 | Inf | Inf | -0.2722 | -0.3540 | 0.4280 | 0.3853 |
| MCF 10A-H2B-mCherry | Alpelisib | 72.62 | 11.8 | Inf | Inf | 0.1179 | 0.2602 | 0.5184 | 0.2709 |