LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 36 | 1.5954 | 57.0859 | 0.1922 | -1.0000 | 0.3071 | 0.3079 |
| MCF 10A-H2B-mCherry | Etoposide | 24 | 2.0061 | 129.7291 | 0.2052 | -1.0000 | 0.2635 | 0.3116 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1462 | 0.1855 | 0.2073 | -0.0474 | 0.3804 | 0.3953 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.0809 | 0.0088 | 0.2144 | 0.3494 | 0.5423 | 0.4143 |
| MCF 10A-H2B-mCherry | Neratinib | 12 | Inf | Inf | 0.2348 | 0.2348 | 0.0000 | 0.4770 |
| MCF 10A-H2B-mCherry | Palbociclib | 72 | 2.3133 | 319.7903 | 0.2433 | -1.0000 | 0.2229 | 0.3116 |
| MCF 10A-H2B-mCherry | Vorinostat | 12 | Inf | Inf | 0.2827 | 0.2827 | 0.0000 | 0.5365 |
| MCF 10A-H2B-mCherry | Palbociclib | 60 | 2.6707 | 808.9177 | 0.3136 | -1.0000 | 0.1923 | 0.3179 |
| MCF 10A-H2B-mCherry | Dasatinib | 48 | 1.2987 | 299.0185 | 0.3294 | -1.0000 | 0.2020 | 0.3592 |
| MCF 10A-H2B-mCherry | Etoposide | 12 | Inf | Inf | 0.3340 | 0.3340 | 0.0000 | 0.4725 |
| MCF 10A-H2B-mCherry | Dasatinib | 36 | 1.8278 | 999.8676 | 0.3368 | -0.9426 | 0.1681 | 0.3611 |
| MCF 10A-H2B-mCherry | Dasatinib | 24 | Inf | Inf | 0.3464 | 0.3464 | 0.0000 | 0.3987 |
| MCF 10A-H2B-mCherry | Trametinib | 72 | 0.0717 | 0.0063 | 0.3482 | 0.3285 | 0.4390 | 0.3784 |
| MCF 10A-H2B-mCherry | Palbociclib | 48 | 3.3346 | 999.9941 | 0.3630 | -0.7979 | 0.1673 | 0.3254 |
| MCF 10A-H2B-mCherry | Trametinib | 84 | 0.1232 | 0.0231 | 0.3664 | 0.2222 | 0.3508 | 0.3587 |
| MCF 10A-H2B-mCherry | Dasatinib | 12 | Inf | Inf | 0.3669 | 0.3669 | 0.0000 | 0.4736 |
| MCF 10A-H2B-mCherry | Palbociclib | 36 | 8.2546 | 999.9626 | 0.4151 | -0.4519 | 0.1342 | 0.3252 |
| MCF 10A-H2B-mCherry | Palbociclib | 24 | Inf | Inf | 0.4526 | 0.4526 | 0.0000 | 0.3423 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.2951 | 0.0015 | 0.5078 | 0.4730 | 0.5502 | 0.3764 |
| MCF 10A-H2B-mCherry | Palbociclib | 12 | Inf | Inf | 0.5376 | 0.5376 | 0.0000 | 0.4133 |
| MCF 10A-H2B-mCherry | Trametinib | 48 | Inf | 0.0005 | 0.5447 | 0.5288 | 0.5177 | 0.3751 |
| MCF 10A-H2B-mCherry | Trametinib | 12 | Inf | Inf | 0.5665 | 0.5665 | 0.0000 | 0.4216 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | Inf | 0.0001 | 0.5993 | 0.6033 | 0.5390 | 0.3548 |
| MCF 10A-H2B-mCherry | Alpelisib | 12 | Inf | Inf | 0.6300 | 0.6300 | 0.0000 | 0.3905 |
| MCF 10A-H2B-mCherry | Alpelisib | 24 | Inf | Inf | 0.6568 | 0.6568 | 0.0000 | 0.2481 |