LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 72 | Inf | Inf | 0.7448 | 0.7448 | 0.0000 | 0.1385 |
| MCF 10A-H2B-mCherry | Alpelisib | 60 | Inf | Inf | 0.7342 | 0.7342 | 0.0000 | 0.1444 |
| MCF 10A-H2B-mCherry | Alpelisib | 84 | Inf | Inf | 0.7193 | 0.7193 | 0.0000 | 0.1230 |
| MCF 10A-H2B-mCherry | Alpelisib | 48 | Inf | Inf | 0.7129 | 0.7129 | 0.0000 | 0.1620 |
| MCF 10A-H2B-mCherry | Alpelisib | 36 | Inf | Inf | 0.6884 | 0.6884 | 0.0000 | 0.1933 |
| MCF 10A-H2B-mCherry | Trametinib | 24 | Inf | Inf | 0.6669 | 0.6669 | 0.0000 | 0.3246 |
| MCF 10A-H2B-mCherry | Alpelisib | 24 | Inf | Inf | 0.6568 | 0.6568 | 0.0000 | 0.2481 |
| MCF 10A-H2B-mCherry | Alpelisib | 12 | Inf | Inf | 0.6300 | 0.6300 | 0.0000 | 0.3905 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | Inf | 0.0001 | 0.5993 | 0.6033 | 0.5390 | 0.3548 |
| MCF 10A-H2B-mCherry | Trametinib | 12 | Inf | Inf | 0.5665 | 0.5665 | 0.0000 | 0.4216 |
| MCF 10A-H2B-mCherry | Palbociclib | 12 | Inf | Inf | 0.5376 | 0.5376 | 0.0000 | 0.4133 |
| MCF 10A-H2B-mCherry | Trametinib | 48 | Inf | 0.0005 | 0.5447 | 0.5288 | 0.5177 | 0.3751 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.2951 | 0.0015 | 0.5078 | 0.4730 | 0.5502 | 0.3764 |
| MCF 10A-H2B-mCherry | Palbociclib | 24 | Inf | Inf | 0.4526 | 0.4526 | 0.0000 | 0.3423 |
| MCF 10A-H2B-mCherry | Dasatinib | 12 | Inf | Inf | 0.3669 | 0.3669 | 0.0000 | 0.4736 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.0809 | 0.0088 | 0.2144 | 0.3494 | 0.5423 | 0.4143 |
| MCF 10A-H2B-mCherry | Dasatinib | 24 | Inf | Inf | 0.3464 | 0.3464 | 0.0000 | 0.3987 |
| MCF 10A-H2B-mCherry | Etoposide | 12 | Inf | Inf | 0.3340 | 0.3340 | 0.0000 | 0.4725 |
| MCF 10A-H2B-mCherry | Trametinib | 72 | 0.0717 | 0.0063 | 0.3482 | 0.3285 | 0.4390 | 0.3784 |
| MCF 10A-H2B-mCherry | Vorinostat | 12 | Inf | Inf | 0.2827 | 0.2827 | 0.0000 | 0.5365 |
| MCF 10A-H2B-mCherry | Neratinib | 12 | Inf | Inf | 0.2348 | 0.2348 | 0.0000 | 0.4770 |
| MCF 10A-H2B-mCherry | Trametinib | 84 | 0.1232 | 0.0231 | 0.3664 | 0.2222 | 0.3508 | 0.3587 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1462 | 0.1855 | 0.2073 | -0.0474 | 0.3804 | 0.3953 |
| MCF 10A-H2B-mCherry | Etoposide | 84 | 0.3533 | 0.6359 | 0.1344 | -0.1515 | 0.4501 | 0.4060 |
| MCF 10A-H2B-mCherry | Vorinostat | 84 | 0.8613 | 1.1591 | -0.0588 | -0.1971 | 1.1191 | 0.3611 |