LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 84 | 0.0009 | 0.0012 | -0.3444 | -0.2890 | 1.3812 | 0.8153 |
| MCF 10A-H2B-mCherry | Taxol | 72 | 0.001 | 0.0013 | -0.3180 | -0.2585 | 1.4036 | 0.7880 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0011 | 0.0014 | -0.3195 | -0.2487 | 1.3756 | 0.7703 |
| MCF 10A-H2B-mCherry | Taxol | 48 | 0.0013 | 0.0019 | -0.3312 | -0.2815 | 1.1758 | 0.7519 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0017 | 0.0028 | -0.3238 | -0.3277 | 0.9300 | 0.7159 |
| MCF 10A-H2B-mCherry | Taxol | 24 | 0.002 | 0.0084 | -0.2083 | -0.5081 | 0.4902 | 0.6573 |
| MCF 10A-H2B-mCherry | Taxol | 12 | 0.0017 | 2.6985 | 0.1492 | -1.0000 | 0.1490 | 0.5622 |
| MCF 10A-H2B-mCherry | Vorinostat | 12 | Inf | Inf | 0.2827 | 0.2827 | 0.0000 | 0.5365 |
| MCF 10A-H2B-mCherry | Neratinib | 12 | Inf | Inf | 0.2348 | 0.2348 | 0.0000 | 0.4770 |
| MCF 10A-H2B-mCherry | Dasatinib | 12 | Inf | Inf | 0.3669 | 0.3669 | 0.0000 | 0.4736 |
| MCF 10A-H2B-mCherry | Etoposide | 12 | Inf | Inf | 0.3340 | 0.3340 | 0.0000 | 0.4725 |
| MCF 10A-H2B-mCherry | Vorinostat | 24 | 0.4754 | 1.7724 | -0.0276 | -0.4821 | 0.5130 | 0.4423 |
| MCF 10A-H2B-mCherry | Vorinostat | 36 | 0.554 | 0.9298 | -0.0652 | -0.2551 | 0.7961 | 0.4258 |
| MCF 10A-H2B-mCherry | Trametinib | 12 | Inf | Inf | 0.5665 | 0.5665 | 0.0000 | 0.4216 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.0809 | 0.0088 | 0.2144 | 0.3494 | 0.5423 | 0.4143 |
| MCF 10A-H2B-mCherry | Palbociclib | 12 | Inf | Inf | 0.5376 | 0.5376 | 0.0000 | 0.4133 |
| MCF 10A-H2B-mCherry | Vorinostat | 48 | 0.6114 | 0.9444 | -0.0821 | -0.2429 | 0.9107 | 0.4110 |
| MCF 10A-H2B-mCherry | Etoposide | 84 | 0.3533 | 0.6359 | 0.1344 | -0.1515 | 0.4501 | 0.4060 |
| MCF 10A-H2B-mCherry | Dasatinib | 24 | Inf | Inf | 0.3464 | 0.3464 | 0.0000 | 0.3987 |
| MCF 10A-H2B-mCherry | Dasatinib | 84 | 0.5642 | 58.6317 | -0.0543 | -1.0000 | 0.2366 | 0.3960 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1462 | 0.1855 | 0.2073 | -0.0474 | 0.3804 | 0.3953 |
| MCF 10A-H2B-mCherry | Alpelisib | 12 | Inf | Inf | 0.6300 | 0.6300 | 0.0000 | 0.3905 |
| MCF 10A-H2B-mCherry | Vorinostat | 60 | 0.7223 | 1.0618 | -0.0810 | -0.2268 | 0.9711 | 0.3866 |
| MCF 10A-H2B-mCherry | Neratinib | 48 | 0.1895 | 4.5797 | 0.0307 | -1.0000 | 0.3449 | 0.3845 |
| MCF 10A-H2B-mCherry | Trametinib | 72 | 0.0717 | 0.0063 | 0.3482 | 0.3285 | 0.4390 | 0.3784 |