LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 8 of 15: End-point dose-response metrics for biological replicate 2. - Dataset (ID:20316)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 12 | Inf | Inf | 0.3263 | 0.3263 | 0.0000 | 0.4338 |
| MCF 10A-H2B-mCherry | Dasatinib | 12 | Inf | Inf | 0.4761 | 0.4761 | 0.0000 | 0.4903 |
| MCF 10A-H2B-mCherry | Alpelisib | 12 | Inf | Inf | 0.5346 | 0.5346 | 0.0000 | 0.4462 |
| MCF 10A-H2B-mCherry | Neratinib | 12 | Inf | Inf | 0.4696 | 0.4696 | 0.0000 | 0.4345 |
| MCF 10A-H2B-mCherry | Palbociclib | 12 | Inf | Inf | 0.4654 | 0.4654 | 0.0000 | 0.4378 |
| MCF 10A-H2B-mCherry | Taxol | 12 | 0.0005 | 0.0007 | 0.2488 | -0.0238 | 0.1003 | 0.5527 |
| MCF 10A-H2B-mCherry | Trametinib | 12 | Inf | Inf | 0.5691 | 0.5691 | 0.0000 | 0.4204 |
| MCF 10A-H2B-mCherry | Vorinostat | 12 | Inf | Inf | 0.4594 | 0.4594 | 0.0000 | 0.4495 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.3492 | 0.0073 | 0.4236 | 0.3755 | 0.3591 | 0.3870 |
| MCF 10A-H2B-mCherry | Vorinostat | 24 | 1.2461 | 204.8226 | 0.2649 | -1.0000 | 0.2153 | 0.3813 |
| MCF 10A-H2B-mCherry | Alpelisib | 24 | Inf | Inf | 0.6050 | 0.6050 | 0.0000 | 0.3309 |
| MCF 10A-H2B-mCherry | Trametinib | 24 | Inf | Inf | 0.7135 | 0.7135 | 0.0000 | 0.3120 |
| MCF 10A-H2B-mCherry | Taxol | 24 | 0.0018 | 0.0505 | -0.2179 | -1.0000 | 0.3299 | 0.6617 |
| MCF 10A-H2B-mCherry | Etoposide | 24 | Inf | Inf | 0.2285 | 0.2285 | 0.0000 | 0.3229 |
| MCF 10A-H2B-mCherry | Dasatinib | 24 | Inf | Inf | 0.3885 | 0.3885 | 0.0000 | 0.4429 |
| MCF 10A-H2B-mCherry | Palbociclib | 24 | Inf | Inf | 0.3926 | 0.3926 | 0.0000 | 0.3827 |
| MCF 10A-H2B-mCherry | Dasatinib | 36 | Inf | Inf | 0.3554 | 0.3554 | 0.0000 | 0.4191 |
| MCF 10A-H2B-mCherry | Etoposide | 36 | 1.7174 | 246.1221 | 0.1871 | -1.0000 | 0.2213 | 0.3418 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1336 | 0.0994 | 0.2934 | 0.0455 | 0.3225 | 0.4123 |
| MCF 10A-H2B-mCherry | Vorinostat | 36 | 1.0852 | 20.5497 | 0.1559 | -1.0000 | 0.3735 | 0.3694 |
| MCF 10A-H2B-mCherry | Palbociclib | 36 | Inf | Inf | 0.3397 | 0.3397 | 0.0000 | 0.3606 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0012 | 0.004 | -0.2810 | -0.4927 | 0.5556 | 0.7513 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | Inf | Inf | 0.6568 | 0.6568 | 0.0000 | 0.3354 |
| MCF 10A-H2B-mCherry | Alpelisib | 36 | Inf | Inf | 0.7055 | 0.7055 | 0.0000 | 0.2829 |
| MCF 10A-H2B-mCherry | Trametinib | 48 | Inf | 0.0003 | 0.5877 | 0.5701 | 0.3964 | 0.3405 |