LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 7 of 15: End-point dose-response metrics for biological replicate 1. - Dataset (ID:20315)

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Cell Small Molecule Time Point (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Neratinib 60
0.1262
0.1133 0.0711 0.0699 1.4052 0.3452
MCF 10A-H2B-mCherry Neratinib 74
0.1646
0.1622 0.0239 0.0094 1.2986 0.3339
MCF 10A-H2B-mCherry Neratinib 85
0.2047
0.2231 -0.0133 -0.0516 1.1390 0.3213
MCF 10A-H2B-mCherry Palbociclib 14
Inf
0.0470 0.6055 0.6286 2.3771 0.2335
MCF 10A-H2B-mCherry Palbociclib 25
0.1608
0.0623 0.3195 0.3100 1.0196 0.4040
MCF 10A-H2B-mCherry Palbociclib 36
0.216
0.1111 0.2237 0.2190 0.8662 0.3977
MCF 10A-H2B-mCherry Palbociclib 49
0.2432
0.1490 0.1924 0.1866 0.9531 0.3867
MCF 10A-H2B-mCherry Palbociclib 60
0.308
0.1983 0.1719 0.1611 0.8830 0.3696
MCF 10A-H2B-mCherry Palbociclib 74
0.3799
0.2585 0.1562 0.1383 0.8411 0.3557
MCF 10A-H2B-mCherry Palbociclib 85
0.4752
0.3445 0.1455 0.1140 0.8049 0.3379
MCF 10A-H2B-mCherry Taxol 14
0.0086
0.0094 -0.3292 -0.2527 5.0000 0.4921
MCF 10A-H2B-mCherry Taxol 25
0.006
0.0088 -0.5788 -0.5111 1.8512 0.6091
MCF 10A-H2B-mCherry Taxol 36
0.0036
0.0060 -0.6322 -0.5696 1.4542 0.6936
MCF 10A-H2B-mCherry Taxol 49
0.0026
0.0045 -0.5907 -0.5232 1.3137 0.7187
MCF 10A-H2B-mCherry Taxol 60
0.0024
0.0038 -0.5376 -0.4605 1.4197 0.7151
MCF 10A-H2B-mCherry Taxol 74
0.0023
0.0034 -0.4930 -0.4115 1.5424 0.7101
MCF 10A-H2B-mCherry Taxol 85
0.0023
0.0033 -0.4886 -0.4051 1.6490 0.7131
MCF 10A-H2B-mCherry Trametinib 14
Inf
0.0076 0.7513 0.8546 4.9986 0.0689
MCF 10A-H2B-mCherry Trametinib 25
0.0129
0.0032 0.4248 0.4682 1.9686 0.3579
MCF 10A-H2B-mCherry Trametinib 36
0.0058
0.0031 0.2898 0.3109 1.5832 0.4664
MCF 10A-H2B-mCherry Trametinib 49
0.0066
0.0040 0.2185 0.2369 1.2900 0.4933
MCF 10A-H2B-mCherry Trametinib 60
0.0078
0.0050 0.1929 0.2064 1.1997 0.4918
MCF 10A-H2B-mCherry Trametinib 74
0.0093
0.0062 0.1778 0.1846 1.1445 0.4863
MCF 10A-H2B-mCherry Trametinib 85
0.0112
0.0077 0.1723 0.1730 1.1413 0.4734
MCF 10A-H2B-mCherry Vorinostat 14
1.2267
0.9430 0.1980 0.1308 1.1529 0.2691