Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 815 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 137.73 NGFR rabbit IgG(H+L) / donkey NGFR 976.81
WM115-B1-rep2
H2
WM-115 Vemurafenib BIX-01294 1.0000 0.5333
uM
 48
hr
 1 1331 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 172.39 NGFR rabbit IgG(H+L) / donkey NGFR 974.77
WM115-B1-rep1
F5
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 909 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 131.83 NGFR rabbit IgG(H+L) / donkey NGFR 973.88
WM115-A2-rep1
H7
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 1372 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 135.88 NGFR rabbit IgG(H+L) / donkey NGFR 973.52
WM115-A2-rep2
A10
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 895 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 133.80 NGFR rabbit IgG(H+L) / donkey NGFR 971.63
WM115-B1-rep2
H8
WM-115 Vemurafenib Anacardic acid 1.0000 0.1067
uM
 48
hr
 1 1092 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 137.00 NGFR rabbit IgG(H+L) / donkey NGFR 967.15
WM115-B2-rep1
G3
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 1314 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 162.02 NGFR rabbit IgG(H+L) / donkey NGFR 966.82
WM115-A2-rep1
A2
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 1297 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 133.03 NGFR rabbit IgG(H+L) / donkey NGFR 965.78
WM115-A2-rep2
A11
WM-115 Vemurafenib Rocilinostat 1.0000 0.5333
uM
 48
hr
 1 1305 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 123.30 NGFR rabbit IgG(H+L) / donkey NGFR 965.10
WM115-B1-rep1
B5
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 929 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 151.87 NGFR rabbit IgG(H+L) / donkey NGFR 964.82
WM115-A2-rep1
A5
WM-115 Vemurafenib IOX2 1.0000 2.6667
uM
 48
hr
 1 1418 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 145.29 NGFR rabbit IgG(H+L) / donkey NGFR 964.73
WM115-A2-rep1
D8
WM-115 Vemurafenib Tranylcypromine 1.0000 2.6667
uM
 48
hr
 1 1043 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 135.10 NGFR rabbit IgG(H+L) / donkey NGFR 964.47
WM115-A2-rep1
G6
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 1076 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 143.73 NGFR rabbit IgG(H+L) / donkey NGFR 961.85
WM115-B1-rep1
H2
WM-115 Vemurafenib C646 1.0000 2.6667
uM
 48
hr
 2 1111 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 119.86 NGFR rabbit IgG(H+L) / donkey NGFR 957.59
WM115-A2-rep2
E3
WM-115 Vemurafenib Vorinostat 1.0000 0.5333
uM
 48
hr
 2 1514 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 135.65 NGFR rabbit IgG(H+L) / donkey NGFR 957.47
WM115-B1-rep2
D2
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 997 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 156.02 NGFR rabbit IgG(H+L) / donkey NGFR 955.42
WM115-A2-rep1
A8
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 976 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 163.14 NGFR rabbit IgG(H+L) / donkey NGFR 952.48
WM115-B1-rep1
H11
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 815 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 132.56 NGFR rabbit IgG(H+L) / donkey NGFR 951.83
WM115-B1-rep2
H3
WM-115 Vemurafenib Decitabine 1.0000 0.5333
uM
 48
hr
 1 1312 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 150.52 NGFR rabbit IgG(H+L) / donkey NGFR 949.09
WM115-B1-rep1
F2
WM-115 Vemurafenib BIX-01294 1.0000 0.5333
uM
 48
hr
 2 1271 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 175.73 NGFR rabbit IgG(H+L) / donkey NGFR 947.40
WM115-B1-rep2
F5
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 1454 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 163.37 NGFR rabbit IgG(H+L) / donkey NGFR 947.23
WM115-A2-rep2
A4
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 1136 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 140.45 NGFR rabbit IgG(H+L) / donkey NGFR 946.39
WM115-B1-rep1
H10
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 939 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 135.31 NGFR rabbit IgG(H+L) / donkey NGFR 946.36
WM115-B2-rep1
H2
WM-115 Vemurafenib Decitabine 1.0000 2.6667
uM
 48
hr
 2 1225 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 142.80 NGFR rabbit IgG(H+L) / donkey NGFR 940.16
WM115-A2-rep2
F2
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 904 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 125.03 NGFR rabbit IgG(H+L) / donkey NGFR 939.97
WM115-B2-rep1
H6