Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
72
hr
3 959 178 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
72
hr
3 9269 446 0.4993 0.5111 0.0481 0.0493
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
72
hr
3 1240 173 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
72
hr
3 1265 236 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
72
hr
3 17086 890 0.9165 1.0000 0.0521 0.0517
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
72
hr
3 16548 819 0.8901 0.8521 0.0495 0.0546
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
72
hr
3 2503 345 0.1387 0.1297 0.1378 0.1366
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
72
hr
3 5232 302 0.3168 0.2809 0.0577 0.0601
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
72
hr
3 824 144 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
72
hr
3 2009 80 0.1240 0.1595 0.0398 0.0410
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
72
hr
3 654 138 0.0332 0.0378 0.2110 0.2000
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
72
hr
3 939 220 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
72
hr
3 17422 897 1.0619 1.0000 0.0515 0.0508
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
72
hr
3 2277 237 0.1311 0.1325 0.1041 0.1040
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
72
hr
3 2567 301 0.1456 0.1296 0.1173 0.1185
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
72
hr
3 628 100 0.0339 0.0441 0.1592 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
72
hr
3 931 209 0.0464 0.0429 0.2245 0.2266
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
72
hr
3 2110 97 0.1294 0.1268 0.0460 0.0491
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
72
hr
3 999 193 0.0518 0.0503 0.1932 0.1892
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
72
hr
3 608 126 0.0310 0.0336 0.2072 0.2228
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
72
hr
3 822 132 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
72
hr
3 2855 318 0.1630 0.1401 0.1114 0.1253
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
72
hr
3 519 103 0.0267 0.0393 0.1985 0.1867
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
72
hr
3 2433 210 0.1258 0.1257 0.0863 0.0985
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
72
hr
3 2021 208 0.1026 0.1203 0.1029 0.1099
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