Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 3 293 135 0.1366 0.1795 0.4608 0.4353
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 294 114 0.1738 0.1625 0.3878 0.4050
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 3 295 140 0.1340 0.1951 0.4746 0.4396
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 3 297 149 0.1280 0.1726 0.5017 0.4923
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 299 45 0.0762 0.1798 0.1505 0.1885
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 303 130 0.1496 0.1631 0.4290 0.3920
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 303 142 0.1555 0.1835 0.4686 0.4751
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 304 159 0.1254 0.1236 0.5230 0.4924
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 305 97 0.1798 0.1631 0.3180 0.3920
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 307 62 0.0735 0.1255 0.2020 0.1549
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 311 137 0.1723 0.1957 0.4405 0.3941
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 311 100 0.1996 0.3166 0.3215 0.3298
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 324 139 0.1599 0.1631 0.4290 0.3920
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 326 114 0.2099 0.3026 0.3497 0.3593
MMAC-SF Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 3 328 69 0.2564 0.2729 0.2104 0.2392
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 328 82 0.0738 0.1794 0.2500 0.2428
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 2 330 152 0.1539 0.1329 0.4606 0.4906
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 332 120 0.2099 0.1957 0.3614 0.3941
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 334 127 0.2050 0.1957 0.3802 0.3941
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 340 166 0.1504 0.1236 0.4882 0.4924
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 342 58 0.0852 0.1670 0.1696 0.1411
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 344 50 0.0882 0.1849 0.1453 0.1624
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 347 187 0.0547 0.0668 0.5389 0.4989
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 2 347 151 0.1695 0.1795 0.4352 0.4353
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 351 175 0.1699 0.1835 0.4986 0.4751