Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1083 745 0.0792 0.0725 0.6879 0.7217
WM-115 Vemurafenib Trametinib Belinostat 1.0000 0.1000 0.0000
uM
 72
hr
 3 1723 572 0.3365 0.3255 0.3320 0.3464
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 344 50 0.0882 0.1849 0.1453 0.1624
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1278 939 0.0795 0.0732 0.7347 0.7378
COLO 858 Vemurafenib Trametinib Belinostat 0.0000 0.0000 0.0000
uM
 72
hr
 3 6638 1181 1.1834 1.0000 0.1779 0.1777
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 307 62 0.0735 0.1255 0.2020 0.1549
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 2094 682 0.3311 0.3340 0.3257 0.3130
A-375 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 3 2640 338 0.1157 0.1234 0.1280 0.1122
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 2090 914 0.3528 0.2705 0.4373 0.4518
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1187 684 0.1179 0.1154 0.5762 0.5851