Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1474 69 1.3292 1.3504 0.0468 0.0554
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 5474 256 1.3752 0.9655 0.0468 0.0440
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 3 1681 85 1.3798 1.2637 0.0506 0.0426
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 1446 46 1.3861 1.3106 0.0318 0.0383
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 1712 76 1.4144 1.2637 0.0444 0.0426
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1585 85 1.4191 1.3504 0.0536 0.0554
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1538 67 1.4203 1.3505 0.0436 0.0426
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 5152 346 1.4263 1.4011 0.0672 0.0616
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1533 83 1.4356 1.3614 0.0541 0.0486
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 4494 264 1.4458 1.4565 0.0587 0.0668
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1549 78 1.4564 1.3614 0.0504 0.0486
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1575 62 1.4609 1.3505 0.0394 0.0426
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 4890 315 1.5637 1.0367 0.0644 0.0669
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 6532 380 1.6214 1.4250 0.0582 0.0566
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 6061 346 1.6960 1.4011 0.0571 0.0616
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 6798 345 1.7007 1.4250 0.0508 0.0566
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 6335 389 2.0324 1.4565 0.0614 0.0668
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 939 220 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 824 144 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1199 182 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1280 253 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1258 245 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1427 243 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 1265 236 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1178 186 NaN NaN NaN NaN