Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 1 751 26 0.6268 0.4801 0.0346 0.0405
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 2821 227 0.6344 0.5869 0.0805 0.0856
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 5372 829 0.6394 0.5738 0.1543 0.1547
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 684 37 0.6406 0.7059 0.0541 0.0474
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2655 180 0.6416 0.6483 0.0678 0.0808
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 2 2431 184 0.6441 0.6307 0.0757 0.0825
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2729 242 0.6447 0.6483 0.0887 0.0808
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 1 2490 221 0.6505 0.6307 0.0888 0.0825
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 11320 265 0.6518 0.6666 0.0234 0.0291
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 710 32 0.6547 0.6350 0.0451 0.0435
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 4507 587 0.6563 0.5804 0.1302 0.1393
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2779 239 0.6585 0.6483 0.0860 0.0808
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2722 220 0.6603 0.7205 0.0808 0.0832
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 794 27 0.6631 0.6202 0.0340 0.0473
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2464 221 0.6656 0.5409 0.0897 0.0829
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 725 32 0.6691 0.6350 0.0441 0.0435
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 11776 362 0.6729 0.6666 0.0307 0.0291
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 1 11842 391 0.6751 0.6666 0.0330 0.0291
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 3017 276 0.6826 0.7484 0.0915 0.0918
COLO 858 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 3 2860 427 0.6890 0.7777 0.1493 0.1530
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 735 34 0.6941 0.6713 0.0463 0.0438
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 1 10027 340 0.6952 0.5962 0.0339 0.0732
WM-115 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 3 2552 153 0.6962 0.7502 0.0600 0.0571
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 4983 821 0.6968 0.8158 0.1648 0.1556
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 859 40 0.7081 0.6202 0.0466 0.0473