Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 626 580 0.0065 0.0069 0.9265 0.9329
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 847 808 0.0065 0.0059 0.9540 0.9563
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 802 763 0.0065 0.0058 0.9514 0.9563
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 3 620 597 0.0065 0.0086 0.9629 0.9481
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 1 506 483 0.0065 0.0086 0.9545 0.9481
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 805 765 0.0066 0.0066 0.9503 0.9516
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1029 988 0.0068 0.0072 0.9602 0.9576
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1028 987 0.0069 0.0076 0.9601 0.9544
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 490 454 0.0070 0.0058 0.9265 0.9410
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 919 876 0.0071 0.0069 0.9532 0.9524
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 977 934 0.0072 0.0072 0.9560 0.9542
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1240 1189 0.0072 0.0087 0.9589 0.9527
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 2 1126 1078 0.0072 0.0070 0.9574 0.9543
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 965 921 0.0073 0.0072 0.9544 0.9576
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 855 811 0.0074 0.0089 0.9485 0.9492
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1361 1317 0.0074 0.0051 0.9677 0.9739
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 888 843 0.0075 0.0076 0.9493 0.9544
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1101 1055 0.0076 0.0072 0.9582 0.9576
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 898 852 0.0076 0.0069 0.9488 0.9524
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 649 610 0.0076 0.0100 0.9399 0.9220
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 860 805 0.0077 0.0101 0.9360 0.9205
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 3 1150 1099 0.0077 0.0098 0.9557 0.9440
COLO 858 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 1 599 572 0.0077 0.0097 0.9549 0.9409
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 1 1068 1016 0.0079 0.0070 0.9513 0.9543
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 483 442 0.0080 0.0074 0.9151 0.9225