Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 783 607 0.0413 0.0413 0.7752 0.7970
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1146 415 0.0414 0.0486 0.3621 0.3602
A-375 Vemurafenib Trametinib Belinostat 0.1000 0.0100 1.0000
uM
 72
hr
 3 1273 725 0.0414 0.0497 0.5695 0.5110
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 1289 1112 0.0415 0.0413 0.8627 0.8498
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 1 1104 933 0.0420 0.0411 0.8451 0.8294
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1299 1000 0.0421 0.0458 0.7698 0.7801
COLO 858 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 2 659 510 0.0422 0.0452 0.7739 0.7587
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 0.3160
uM
 72
hr
 2 983 766 0.0423 0.0457 0.7792 0.7894
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 3 1107 827 0.0423 0.0438 0.7471 0.7492
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1232 483 0.0424 0.0422 0.3920 0.3824
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1298 1043 0.0427 0.0484 0.8035 0.7812
A-375 Vemurafenib Trametinib Belinostat 0.1000 0.0100 1.0000
uM
 72
hr
 1 1454 889 0.0427 0.0497 0.6114 0.5110
A-375 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 1127 370 0.0428 0.0503 0.3283 0.3253
COLO 858 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 3 776 578 0.0429 0.0538 0.7448 0.7062
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 0.3160
uM
 72
hr
 1 1138 917 0.0430 0.0457 0.8058 0.7894
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 1 1491 1204 0.0433 0.0226 0.8075 0.8932
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 2 1234 945 0.0436 0.0470 0.7658 0.7476
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 3 971 390 0.0439 0.0434 0.4016 0.4431
A-375 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 2 1431 831 0.0439 0.0409 0.5807 0.5956
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 3 738 559 0.0439 0.0332 0.7575 0.8226
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 818 134 0.0440 0.0441 0.1638 0.1675
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 2 1143 848 0.0445 0.0438 0.7419 0.7492
A-375 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 1269 481 0.0446 0.0542 0.3790 0.3430
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 890 196 0.0446 0.0429 0.2202 0.2266
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 1226 930 0.0447 0.0438 0.7586 0.7492