Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1171 1145 0.0044 0.0051 0.9778 0.9739
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1361 1317 0.0074 0.0051 0.9677 0.9739
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 596 563 0.0064 0.0053 0.9446 0.9453
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 3 390 366 0.0047 0.0053 0.9385 0.9453
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 530 505 0.0049 0.0053 0.9528 0.9453
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 903 859 0.0062 0.0055 0.9513 0.9565
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 972 934 0.0053 0.0055 0.9609 0.9565
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 820 785 0.0049 0.0055 0.9573 0.9565
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 802 763 0.0065 0.0058 0.9514 0.9563
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 581 559 0.0043 0.0058 0.9621 0.9410
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 490 454 0.0070 0.0058 0.9265 0.9410
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 754 726 0.0046 0.0058 0.9629 0.9563
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 762 730 0.0054 0.0058 0.9580 0.9500
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 781 744 0.0062 0.0058 0.9526 0.9500
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 473 442 0.0060 0.0058 0.9345 0.9410
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 578 543 0.0059 0.0058 0.9394 0.9500
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 836 798 0.0063 0.0058 0.9545 0.9563
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 721 688 0.0055 0.0059 0.9542 0.9563
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 868 834 0.0057 0.0059 0.9608 0.9563
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 847 808 0.0065 0.0059 0.9540 0.9563
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 805 765 0.0066 0.0066 0.9503 0.9516
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 683 654 0.0048 0.0066 0.9575 0.9516
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 959 908 0.0085 0.0066 0.9468 0.9516
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 687 670 0.0033 0.0068 0.9753 0.9483
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 564 520 0.0086 0.0068 0.9220 0.9483