Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1258 460 0.2069 0.2287 0.3657 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1469 527 0.2442 0.2287 0.3587 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1478 571 0.2351 0.2287 0.3863 0.3702
WM-115 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1647 700 0.2499 0.2290 0.4250 0.4257
WM-115 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1550 676 0.2307 0.2290 0.4361 0.4257
WM-115 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1339 557 0.2064 0.2290 0.4160 0.4257
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1620 904 0.1890 0.1786 0.5580 0.5384
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1445 784 0.1745 0.1786 0.5426 0.5384
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1345 692 0.1723 0.1786 0.5145 0.5384
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1805 177 0.4221 0.4571 0.0981 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1951 168 0.4622 0.4571 0.0861 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2060 182 0.4869 0.4571 0.0883 0.0908
A-375 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 3 1153 339 0.0480 0.0636 0.2940 0.2746
A-375 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 2 1570 391 0.0695 0.0636 0.2490 0.2746
A-375 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 1 1727 485 0.0732 0.0636 0.2808 0.2746
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1430 818 0.1615 0.1457 0.5720 0.5805
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 1323 813 0.1346 0.1457 0.6145 0.5805
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 1200 666 0.1409 0.1457 0.5550 0.5805
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1202 841 0.0953 0.0943 0.6997 0.7022
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 1234 857 0.0995 0.0943 0.6945 0.7022
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 1162 828 0.0881 0.0943 0.7126 0.7022
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 937 801 0.0319 0.0294 0.8549 0.8675
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 934 810 0.0291 0.0294 0.8672 0.8675
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 969 853 0.0272 0.0294 0.8803 0.8675
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 1031 35 0.9423 0.7329 0.0339 0.0348