Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 356 158 0.1912 0.1986 0.4438 0.4158
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 223 93 0.1255 0.1986 0.4170 0.4158
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 286 117 0.1632 0.1361 0.4091 0.3969
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 218 79 0.1342 0.1361 0.3624 0.3969
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 198 83 0.1110 0.1361 0.4192 0.3969
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 3 1058 548 0.1247 0.1437 0.5180 0.4715
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 1136 503 0.1548 0.1437 0.4428 0.4715
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 1135 515 0.1516 0.1437 0.4537 0.4715
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 3 1196 603 0.1450 0.1491 0.5042 0.5301
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 2 1295 708 0.1436 0.1491 0.5467 0.5301
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 1409 760 0.1587 0.1491 0.5394 0.5301
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 1298 665 0.1548 0.1469 0.5123 0.5450
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 1309 727 0.1423 0.1469 0.5554 0.5450
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 1357 770 0.1436 0.1469 0.5674 0.5450
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 1758 908 0.2079 0.2020 0.5165 0.5127
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 2 1550 773 0.1900 0.2020 0.4987 0.5127
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 1784 933 0.2081 0.2020 0.5230 0.5127
WM-115 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 1 1261 597 0.1927 0.2080 0.4734 0.4511
WM-115 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 2 1353 550 0.2330 0.2080 0.4065 0.4511
WM-115 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 3 1297 614 0.1982 0.2080 0.4734 0.4511
WM-115 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 1 775 600 0.0508 0.0514 0.7742 0.7604
WM-115 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 2 737 556 0.0525 0.0514 0.7544 0.7604
WM-115 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 3 707 532 0.0508 0.0514 0.7525 0.7604
COLO 858 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 1 617 518 0.0215 0.0184 0.8395 0.8831
COLO 858 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 2 797 720 0.0167 0.0184 0.9034 0.8831