Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1308 538 0.1996 0.1880 0.4113 0.4385
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1378 635 0.1926 0.2175 0.4608 0.4311
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1535 647 0.2302 0.2175 0.4215 0.4311
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1504 618 0.2297 0.2175 0.4109 0.4311
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1557 724 0.2160 0.2121 0.4650 0.4516
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1464 651 0.2108 0.2121 0.4447 0.4516
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 1456 648 0.2095 0.2121 0.4451 0.4516
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1754 586 0.3028 0.2983 0.3341 0.3439
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1881 656 0.3176 0.2983 0.3488 0.3439
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 1626 567 0.2745 0.2983 0.3487 0.3439
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1258 460 0.2069 0.2287 0.3657 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1469 527 0.2442 0.2287 0.3587 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1478 571 0.2351 0.2287 0.3863 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 1635 606 0.2668 0.2819 0.3706 0.3543
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1705 584 0.2906 0.2819 0.3425 0.3543
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1710 598 0.2883 0.2819 0.3497 0.3543
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1811 662 0.2979 0.2794 0.3655 0.3819
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1717 659 0.2743 0.2794 0.3838 0.3819
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1700 674 0.2660 0.2794 0.3965 0.3819
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 2000 595 0.3642 0.3574 0.2975 0.2896
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 1909 546 0.3534 0.3574 0.2860 0.2896
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 1914 546 0.3546 0.3574 0.2853 0.2896
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1805 177 0.4221 0.4571 0.0981 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1951 168 0.4622 0.4571 0.0861 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2060 182 0.4869 0.4571 0.0883 0.0908