Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 849 828 0.0035 0.0045 0.9753 0.9731
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1204 1175 0.0048 0.0045 0.9759 0.9731
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 712 695 0.0028 0.0029 0.9761 0.9759
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 929 907 0.0037 0.0051 0.9763 0.9739
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 717 700 0.0028 0.0030 0.9763 0.9776
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 975 952 0.0038 0.0030 0.9764 0.9776
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1237 1209 0.0046 0.0049 0.9774 0.9743
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1171 1145 0.0044 0.0051 0.9778 0.9739
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1083 1059 0.0040 0.0044 0.9778 0.9751
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1387 1358 0.0048 0.0049 0.9791 0.9743
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 914 895 0.0032 0.0029 0.9792 0.9759
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1164 1140 0.0040 0.0044 0.9794 0.9751
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 707 693 0.0023 0.0030 0.9802 0.9776
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 626 614 0.0020 0.0020 0.9808 0.9824
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 839 825 0.0023 0.0038 0.9833 0.9738
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 711 706 0.0008 0.0020 0.9930 0.9824
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 2 158 157 0.0009 0.1712 0.9937 0.5833
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1199 182 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1427 243 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1258 245 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 1231 219 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1240 173 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 1356 203 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1280 253 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1027 243 NaN NaN NaN NaN