Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 3395 272 0.8096 0.8287 0.0801 0.0771
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 3 7321 587 0.4675 0.5250 0.0802 0.0831
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 2836 228 0.8914 1.4565 0.0804 0.0668
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 2821 227 0.6344 0.5869 0.0805 0.0856
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2722 220 0.6603 0.7205 0.0808 0.0832
WM-115 Vemurafenib Trametinib Belinostat 0.0000 0.0000 1.0000
uM
 72
hr
 3 1733 142 0.4651 0.4681 0.0819 0.0978
A-375 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 3 1813 150 0.1216 0.1126 0.0827 0.0954
A-375 Vemurafenib Trametinib I-BET 0.3160 0.0316 0.0000
uM
 72
hr
 2 1401 116 0.0922 0.0967 0.0828 0.1087
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 2538 211 0.5691 0.5869 0.0831 0.0856
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 3 2273 189 0.5974 0.6307 0.0832 0.0825
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 2 7782 655 0.4948 0.5250 0.0842 0.0831
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 1 9641 818 0.6126 0.5250 0.0848 0.0831
A-375 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 3 1730 147 0.1157 0.1055 0.0850 0.0998
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2300 197 0.6241 0.5409 0.0857 0.0829
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2779 239 0.6585 0.6483 0.0860 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1951 168 0.4622 0.4571 0.0861 0.0908
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 2433 210 0.1258 0.1257 0.0863 0.0985
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 3280 283 0.7463 0.7484 0.0863 0.0918
A-375 Vemurafenib Trametinib I-BET 0.1000 0.0100 0.0000
uM
 72
hr
 3 1678 145 0.1100 0.1110 0.0864 0.0898
A-375 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 3 2511 217 0.1352 0.1384 0.0864 0.0909
A-375 Vemurafenib Trametinib I-BET151 1.0000 0.1000 0.0000
uM
 72
hr
 3 1787 155 0.1133 0.1188 0.0867 0.0994
A-375 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 2 2615 230 0.1406 0.1384 0.0880 0.0909
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 3452 304 0.7699 0.7973 0.0881 0.0750
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2060 182 0.4869 0.4571 0.0883 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2729 242 0.6447 0.6483 0.0887 0.0808