Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 914 895 0.0032 0.0029 0.9792 0.9759
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 668 650 0.0030 0.0042 0.9731 0.9671
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 712 695 0.0028 0.0029 0.9761 0.9759
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 717 700 0.0028 0.0030 0.9763 0.9776
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 618 601 0.0028 0.0029 0.9725 0.9759
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 707 693 0.0023 0.0030 0.9802 0.9776
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 839 825 0.0023 0.0038 0.9833 0.9738
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 626 614 0.0020 0.0020 0.9808 0.9824
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 2 158 157 0.0009 0.1712 0.9937 0.5833
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 711 706 0.0008 0.0020 0.9930 0.9824