Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1550 676 0.2307 0.2290 0.4361 0.4257
WM-115 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1339 557 0.2064 0.2290 0.4160 0.4257
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1987 748 0.3270 0.3049 0.3764 0.3755
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1970 760 0.3193 0.3049 0.3858 0.3755
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 4353 259 0.9599 1.0000 0.0595 0.0618
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 4661 287 1.0256 1.0000 0.0616 0.0618
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 2739 569 0.5088 0.5131 0.2077 0.2141
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 2874 628 0.5266 0.5131 0.2185 0.2141
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2691 483 0.5177 0.5260 0.1795 0.1772
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2843 489 0.5519 0.5260 0.1720 0.1772
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2129 338 0.4199 0.4392 0.1588 0.1684
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2374 353 0.4739 0.4392 0.1487 0.1684
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1368 883 0.1137 0.1195 0.6455 0.6100
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1302 783 0.1217 0.1195 0.6014 0.6100
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1238 740 0.1168 0.1322 0.5977 0.5586
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1344 776 0.1332 0.1322 0.5774 0.5586
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1153 685 0.1097 0.1154 0.5941 0.5851
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1187 684 0.1179 0.1154 0.5762 0.5851
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 2070 643 0.3346 0.3340 0.3106 0.3130
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 2094 682 0.3311 0.3340 0.3257 0.3130
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1066 785 0.0659 0.0725 0.7364 0.7217
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1083 745 0.0792 0.0725 0.6879 0.7217
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1169 905 0.0619 0.0635 0.7742 0.7648
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1445 784 0.1745 0.1786 0.5426 0.5384
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1620 904 0.1890 0.1786 0.5580 0.5384