Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 3 1197 632 0.1610 0.1939 0.5280 0.5515
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 0.0000
uM
 72
hr
 1 762 507 0.0726 0.1073 0.6654 0.6402
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 0.0000
uM
 72
hr
 2 1177 751 0.1214 0.1073 0.6381 0.6402
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 0.0000
uM
 72
hr
 3 1173 724 0.1279 0.1073 0.6172 0.6402
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 1 1324 1269 0.0157 0.0146 0.9585 0.9538
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 2 1202 1146 0.0160 0.0146 0.9534 0.9538
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 3 853 810 0.0122 0.0146 0.9496 0.9538
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 1 733 499 0.0667 0.0750 0.6808 0.7017
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 2 936 681 0.0726 0.0750 0.7276 0.7017
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 3 993 692 0.0857 0.0750 0.6969 0.7017
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 1 791 750 0.0117 0.0132 0.9482 0.9444
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 2 1005 947 0.0165 0.0132 0.9423 0.9444
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 3 698 658 0.0114 0.0132 0.9427 0.9444
COLO 858 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 1 723 547 0.0501 0.0553 0.7566 0.7304
COLO 858 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 2 692 523 0.0481 0.0553 0.7558 0.7304
COLO 858 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 3 738 501 0.0675 0.0553 0.6789 0.7304
COLO 858 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 1.0000
uM
 72
hr
 1 878 818 0.0171 0.0118 0.9317 0.9447
COLO 858 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 1.0000
uM
 72
hr
 2 756 728 0.0080 0.0118 0.9630 0.9447
COLO 858 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 1.0000
uM
 72
hr
 3 594 558 0.0103 0.0118 0.9394 0.9447
COLO 858 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 1 511 445 0.0188 0.0164 0.8708 0.8891
COLO 858 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 2 537 469 0.0194 0.0164 0.8734 0.8891
COLO 858 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 3 508 469 0.0111 0.0164 0.9232 0.8891
COLO 858 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 1 599 572 0.0077 0.0097 0.9549 0.9409
COLO 858 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 2 578 537 0.0117 0.0097 0.9291 0.9409
COLO 858 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 3 556 522 0.0097 0.0097 0.9388 0.9409