Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 1 486 455 0.0056 0.0041 0.9362 0.9488
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 2 424 402 0.0040 0.0041 0.9481 0.9488
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 3 422 406 0.0029 0.0041 0.9621 0.9488
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 850 795 0.0065 0.0047 0.9353 0.9535
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 1 921 884 0.0044 0.0047 0.9598 0.9535
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 809 781 0.0033 0.0047 0.9654 0.9535
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 726 696 0.0051 0.0054 0.9587 0.9547
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 1 661 623 0.0064 0.0054 0.9425 0.9547
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 3 752 724 0.0047 0.0054 0.9628 0.9547
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 595 559 0.0065 0.0058 0.9395 0.9416
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 3 477 452 0.0045 0.0058 0.9476 0.9416
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 2 561 526 0.0063 0.0058 0.9376 0.9416
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 937 901 0.0051 0.0064 0.9616 0.9579
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 1 1135 1078 0.0081 0.0064 0.9498 0.9579
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 3 1090 1049 0.0059 0.0064 0.9624 0.9579
COLO 858 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 2 1444 1385 0.0070 0.0077 0.9591 0.9513
COLO 858 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 1 1509 1433 0.0090 0.0077 0.9496 0.9513
COLO 858 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 1094 1034 0.0071 0.0077 0.9452 0.9513
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 1556 1484 0.0085 0.0082 0.9537 0.9545
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 3 1488 1416 0.0085 0.0082 0.9516 0.9545
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 2 1479 1417 0.0074 0.0082 0.9581 0.9545
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 2 1275 1218 0.0081 0.0084 0.9553 0.9531
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 1 1440 1382 0.0083 0.0084 0.9597 0.9531
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 1093 1032 0.0087 0.0084 0.9442 0.9531
COLO 858 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 2 759 722 0.0061 0.0089 0.9513 0.9423
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