Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 2 878 144 0.2118 0.1862 0.1640 0.1658
MMAC-SF Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 1 881 194 0.4233 0.4219 0.2202 0.2479
MMAC-SF Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 881 262 0.3814 0.3551 0.2974 0.3208
MMAC-SF Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 3 882 92 0.6051 0.5813 0.1043 0.1242
MMAC-SF Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 885 43 0.6449 0.7202 0.0486 0.0513
MMAC-SF Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 887 228 0.4060 0.4219 0.2570 0.2479
MMAC-SF Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 1 893 157 0.4535 0.5003 0.1758 0.1840
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 894 41 0.8637 0.8032 0.0459 0.0480
MZ7-mel Vemurafenib JNK-IN-8 1.000 3.160
uM
 72
hr
 2 895 190 0.2235 0.2060 0.2123 0.1979
MMAC-SF Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 2 896 69 0.6334 0.6145 0.0770 0.0615
MMAC-SF Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 1 898 135 0.5844 0.4386 0.1503 0.1472
MMAC-SF Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 898 102 0.4904 0.4387 0.1136 0.1238
MZ7-mel Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 3 898 64 0.2406 0.4111 0.0713 0.0604
MMAC-SF Vemurafenib JNK-IN-8 1.000 0.000
uM
 72
hr
 3 900 279 0.6098 0.5178 0.3100 0.3105
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 2 901 55 0.8308 0.8164 0.0610 0.0519
MMAC-SF Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 901 34 0.6918 0.6184 0.0377 0.0487
COLO 858 Vemurafenib Belinostat 0.000 1.000
uM
 72
hr
 2 902 333 0.1306 0.1295 0.3692 0.3690
MMAC-SF Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 1 904 113 0.4874 0.4387 0.1250 0.1238
COLO 858 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 2 904 415 0.1484 0.1822 0.4591 0.4375
MMAC-SF Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 3 910 34 0.5397 0.6001 0.0374 0.0364
COLO 858 Vemurafenib JNK-IN-8 3.160 0.316
uM
 72
hr
 2 911 825 0.0143 0.0166 0.9056 0.8947
MZ7-mel Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 3 911 96 0.2351 0.3742 0.1054 0.0960
MMAC-SF Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 2 912 51 0.6870 0.6184 0.0559 0.0487
MMAC-SF Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 3 912 245 0.5322 0.5481 0.2686 0.2669
COLO 858 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 1 912 724 0.0339 0.0290 0.7939 0.7843