Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 1 912 724 0.0339 0.0290 0.7939 0.7843
A-375 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 1 1292 66 0.0621 0.0577 0.0511 0.0487
WM-115 Vemurafenib JNK-IN-8 3.160 0.316
uM
 72
hr
 1 1731 422 0.3311 0.3217 0.2438 0.2378
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 1 1748 230 0.2738 0.2879 0.1316 0.1549
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 9635 173 0.4953 0.4364 0.0180 0.0207
A-375 Vemurafenib Belinostat 0.100 0.000
uM
 72
hr
 1 6493 153 0.4841 0.4690 0.0236 0.0238
COLO 858 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 1 1301 460 0.1517 0.1439 0.3536 0.3763
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 11677 368 0.7113 0.6866 0.0315 0.0312
A-375 Vemurafenib Belinostat 0.316 1.000
uM
 72
hr
 1 1495 539 0.0730 0.0676 0.3605 0.4031
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 1 1035 564 0.0849 0.0793 0.5449 0.5384
A-375 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 5747 125 0.2943 0.3050 0.0218 0.0212
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 595 559 0.0065 0.0058 0.9395 0.9416
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 1 526 473 0.0096 0.0109 0.8992 0.8930
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
COLO 858 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 1 1042 801 0.0435 0.0334 0.7687 0.8371
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 1 1250 489 0.1372 0.1377 0.3912 0.4424
A-375 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 1 4016 78 0.2061 0.2010 0.0194 0.0218
A-375 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 3389 65 0.1683 0.1709 0.0192 0.0246
COLO 858 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 1 1154 797 0.0644 0.0514 0.6906 0.7028
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 5745 285 0.3434 0.2974 0.0496 0.0491
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 1 1199 1142 0.0103 0.0092 0.9525 0.9423
COLO 858 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 1 942 775 0.0301 0.0248 0.8227 0.8407
A-375 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 1 3954 69 0.2034 0.1687 0.0175 0.0176
A-375 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 1 4169 116 0.2972 0.2900 0.0278 0.0255
A-375 Vemurafenib I-BET 0.100 1.000
uM
 72
hr
 1 4909 225 0.3435 0.3080 0.0458 0.0484