Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 2 1274 753 0.0744 0.0748 0.5911 0.5989
A-375 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 1822 269 0.0744 0.0857 0.1476 0.1490
A-375 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 3 1534 520 0.0744 0.0866 0.3390 0.3091
A-375 Vemurafenib JNK-IN-8 1.000 3.160
uM
 72
hr
 3 1458 273 0.0745 0.0897 0.1872 0.1612
A-375 Vemurafenib (+)-JQ1 0.316 1.000
uM
 72
hr
 3 1536 471 0.0753 0.0952 0.3066 0.3084
COLO 858 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 1 1374 845 0.0756 0.0722 0.6150 0.5817
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 3 1163 835 0.0758 0.0871 0.7180 0.7176
A-375 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 3 1653 605 0.0758 0.0884 0.3660 0.3475
COLO 858 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 2 1336 1087 0.0761 0.0728 0.8136 0.8214
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 1 1347 812 0.0764 0.0748 0.6028 0.5989
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 1 972 720 0.0765 0.0787 0.7407 0.7868
A-375 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 1899 295 0.0769 0.0825 0.1553 0.1694
A-375 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 2 1849 762 0.0769 0.0702 0.4121 0.4350
COLO 858 Vemurafenib Belinostat 3.160 0.000
uM
 72
hr
 3 1747 1411 0.0771 0.0685 0.8077 0.8137
COLO 858 Vemurafenib Belinostat 1.000 1.000
uM
 72
hr
 3 1002 665 0.0773 0.0829 0.6637 0.6809
COLO 858 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 2 1227 686 0.0773 0.0722 0.5591 0.5817
A-375 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 1 1979 884 0.0774 0.0702 0.4467 0.4350
A-375 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 1 1638 157 0.0775 0.0717 0.0958 0.0989
COLO 858 Vemurafenib (+)-JQ1 0.316 1.000
uM
 72
hr
 3 923 667 0.0777 0.0899 0.7226 0.7359
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 2 1554 62 0.0781 0.0757 0.0399 0.0403
A-375 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 1 1622 180 0.0784 0.0695 0.1110 0.1086
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 3 1480 1221 0.0786 0.0787 0.8250 0.7868
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 3 1744 239 0.0788 0.0842 0.1370 0.1524
COLO 858 Vemurafenib Belinostat 1.000 1.000
uM
 72
hr
 1 1214 870 0.0789 0.0829 0.7166 0.6809
COLO 858 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 2 1263 917 0.0794 0.0767 0.7260 0.7291