Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 2 3775 147 1.0466 0.9528 0.0389 0.0436
COLO 858 Vemurafenib I-BET151 0.100 0.000
uM
 72
hr
 2 2385 147 0.5172 0.4925 0.0616 0.0680
WM-115 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 1877 148 0.4133 0.4405 0.0788 0.0768
MMAC-SF Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 1 616 148 0.3584 0.4029 0.2403 0.2375
A-375 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 3 3001 148 0.2018 0.1959 0.0493 0.0416
A-375 Vemurafenib (+)-JQ1 0.316 0.000
uM
 72
hr
 2 4098 148 0.2793 0.2957 0.0361 0.0383
MZ7-mel Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 2302 149 0.4731 0.3676 0.0647 0.0695
A-375 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 2 1440 149 0.0702 0.0695 0.1035 0.1086
MZ7-mel Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 2703 149 0.5612 0.6005 0.0551 0.0470
MZ7-mel Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 2225 149 0.4562 0.4826 0.0670 0.0734
MZ7-mel Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 3 1605 149 0.4749 0.9734 0.0928 0.0805
A-375 Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 1 5186 150 0.2413 0.2413 0.0289 0.0233
MMAC-SF Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 465 150 0.2413 0.2538 0.3226 0.3464
A-375 Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 2 6306 150 0.3872 0.3831 0.0238 0.0229
MZ7-mel Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 1 2574 151 0.7682 0.5584 0.0587 0.0586
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 3676 151 0.1689 0.1741 0.0411 0.0433
MZ7-mel Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 1 2545 151 0.4814 0.4188 0.0593 0.0678
MMAC-SF Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 2 859 151 0.5423 0.5371 0.1758 0.1786
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 3 3917 151 0.1971 0.1915 0.0385 0.0418
A-375 Vemurafenib Belinostat 0.316 0.000
uM
 72
hr
 2 3734 151 0.2736 0.2662 0.0404 0.0401
MZ7-mel Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 2708 151 0.8340 0.7361 0.0558 0.0573
A-375 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 1 1428 152 0.0694 0.0541 0.1064 0.1374
WM-115 Vemurafenib I-BET 0.100 0.000
uM
 72
hr
 3 3445 152 0.9446 0.9015 0.0441 0.0495
A-375 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 2 4409 152 0.3077 0.3027 0.0345 0.0319
WM-115 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 1912 153 0.4204 0.4405 0.0800 0.0768