Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 2 1837 96 0.3501 0.3242 0.0523 0.0687
MMAC-SF Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 1 682 97 0.5745 0.6805 0.1422 0.1572
A-375 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 2 5069 97 0.2705 0.2505 0.0191 0.0221
MMAC-SF Vemurafenib JNK-IN-8 0.316 0.316
uM
 72
hr
 1 714 97 0.6059 0.6759 0.1359 0.1363
A-375 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 4191 97 0.1962 0.1926 0.0231 0.0248
A-375 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 1 4202 97 0.1967 0.1926 0.0231 0.0248
MZ7-mel Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 1603 97 0.4912 0.3835 0.0605 0.0574
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 1603 97 1.1534 1.0853 0.0605 0.0619
MMAC-SF Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 1 642 98 0.5508 0.6679 0.1526 0.1517
MMAC-SF Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 1 1062 98 0.5940 0.5287 0.0923 0.0889
A-375 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 3 2902 98 0.1420 0.1658 0.0338 0.0359
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 1 250 98 0.1539 0.1255 0.3920 0.4181
MMAC-SF Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 2 788 98 0.5505 0.4894 0.1244 0.1367
MMAC-SF Vemurafenib JNK-IN-8 1.000 3.160
uM
 72
hr
 2 519 99 0.4124 0.4579 0.1908 0.1782
A-375 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 1 6033 99 0.3228 0.3515 0.0164 0.0163
A-375 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 3533 99 0.1739 0.1709 0.0280 0.0246
MZ7-mel Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 2 1663 100 0.3143 0.3143 0.0601 0.0600
A-375 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 2 3786 100 0.2005 0.1991 0.0264 0.0233
MMAC-SF Vemurafenib JNK-IN-8 1.000 1.000
uM
 72
hr
 3 515 100 0.4075 0.5227 0.1942 0.1868
MMAC-SF Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 255 100 0.1569 0.2379 0.3922 0.3676
MZ7-mel Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 1 1146 101 0.2101 0.1839 0.0881 0.0837
WM-115 Vemurafenib Belinostat 0.000 1.000
uM
 72
hr
 1 2039 101 0.5557 0.4993 0.0495 0.0637
MMAC-SF Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 1 782 102 0.5208 0.5813 0.1304 0.1242
A-375 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 3 6696 102 0.3587 0.3515 0.0152 0.0163
MMAC-SF Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 898 102 0.4904 0.4387 0.1136 0.1238