Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 22233 990 1.0180 1.0000 0.0445 0.0468
A-375 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 2 14840 1490 0.9441 1.0000 0.1004 0.0814
A-375 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 1 17083 736 1.1561 1.0000 0.0431 0.0814
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 15089 638 0.9090 1.0016 0.0423 0.0383
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 16836 650 1.0181 1.0016 0.0386 0.0383
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 17737 603 1.0777 1.0016 0.0340 0.0383
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 1676 108 1.2009 1.0853 0.0644 0.0619
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 1253 76 0.9015 1.0853 0.0607 0.0619
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 1603 97 1.1534 1.0853 0.0605 0.0619
MMAC-SF Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 2014 89 1.1861 1.1047 0.0442 0.0462
MMAC-SF Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 1508 67 0.8879 1.1047 0.0444 0.0462
MMAC-SF Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 2119 106 1.2403 1.1047 0.0500 0.0462
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 4690 306 0.9633 1.1499 0.0652 0.0651
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 6060 359 1.2527 1.1499 0.0592 0.0651
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 6042 428 1.2336 1.1499 0.0708 0.0651
MMAC-SF Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 2 1398 83 1.3314 1.2926 0.0594 0.0509
MMAC-SF Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 1 1207 52 1.1694 1.2926 0.0431 0.0509
MMAC-SF Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 3 1432 72 1.3770 1.2926 0.0503 0.0509
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 1846 89 1.4019 1.3011 0.0482 0.0459
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 1771 79 1.3500 1.3011 0.0446 0.0459
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 1511 68 1.1513 1.3011 0.0450 0.0459
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 1158 56 1.0822 1.3028 0.0484 0.0415
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 1476 60 1.3905 1.3028 0.0407 0.0415