Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 2941 145 0.8865 0.7710 0.0493 0.0544
MZ7-mel Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 2 2697 158 0.8050 0.7710 0.0586 0.0544
WM-115 Vemurafenib I-BET151 0.000 1.000
uM
 72
hr
 2 2815 155 0.7624 0.7766 0.0551 0.0532
WM-115 Vemurafenib I-BET151 0.000 1.000
uM
 72
hr
 1 3143 166 0.8533 0.7766 0.0528 0.0532
WM-115 Vemurafenib I-BET151 0.000 1.000
uM
 72
hr
 3 2628 136 0.7142 0.7766 0.0518 0.0532
WM-115 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 1 2875 195 0.7688 0.7817 0.0678 0.0634
WM-115 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 3 2983 183 0.8032 0.7817 0.0613 0.0634
WM-115 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 2 2870 175 0.7731 0.7817 0.0610 0.0634
WM-115 Vemurafenib (+)-JQ1 0.316 0.000
uM
 72
hr
 3 2794 188 0.7996 0.7819 0.0673 0.0740
WM-115 Vemurafenib (+)-JQ1 0.316 0.000
uM
 72
hr
 1 2680 212 0.7572 0.7819 0.0791 0.0740
WM-115 Vemurafenib (+)-JQ1 0.316 0.000
uM
 72
hr
 2 2781 210 0.7888 0.7819 0.0755 0.0740
MMAC-SF Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 2 1093 67 0.8186 0.7894 0.0613 0.0654
MMAC-SF Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 3 1098 69 0.8210 0.7894 0.0628 0.0654
MMAC-SF Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 1 984 71 0.7285 0.7894 0.0722 0.0654
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 591 30 0.5509 0.7915 0.0508 0.0491
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 1095 43 1.0331 0.7915 0.0393 0.0491
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 854 49 0.7905 0.7915 0.0574 0.0491
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 1047 45 0.7995 0.7976 0.0430 0.0486
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 981 39 0.7516 0.7976 0.0398 0.0486
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 2 1126 71 0.8418 0.7976 0.0631 0.0486
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 894 41 0.8637 0.8032 0.0459 0.0480
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 1 736 41 0.7037 0.8032 0.0557 0.0480
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 3 869 37 0.8424 0.8032 0.0426 0.0480
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 950 43 0.8907 0.8036 0.0453 0.0497
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 2 913 53 0.8445 0.8036 0.0581 0.0497