Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib JNK-IN-8 1.000 0.316
uM
 72
hr
 2 2861 198 0.1675 0.1694 0.0692 0.0638
MZ7-mel Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 3 1067 253 0.1789 0.1699 0.2371 0.2362
MZ7-mel Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 2 1140 287 0.1874 0.1699 0.2518 0.2362
MZ7-mel Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 837 184 0.1435 0.1699 0.2198 0.2362
A-375 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 3533 99 0.1739 0.1709 0.0280 0.0246
A-375 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 2 3458 92 0.1704 0.1709 0.0266 0.0246
A-375 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 3389 65 0.1683 0.1709 0.0192 0.0246
COLO 858 Vemurafenib JNK-IN-8 0.316 0.316
uM
 72
hr
 3 1488 457 0.1710 0.1736 0.3071 0.3188
COLO 858 Vemurafenib JNK-IN-8 0.316 0.316
uM
 72
hr
 2 1562 528 0.1715 0.1736 0.3380 0.3188
COLO 858 Vemurafenib JNK-IN-8 0.316 0.316
uM
 72
hr
 1 1562 486 0.1784 0.1736 0.3111 0.3188
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 3676 151 0.1689 0.1741 0.0411 0.0433
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 2 3938 167 0.1807 0.1741 0.0424 0.0433
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 3779 175 0.1727 0.1741 0.0463 0.0433
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 2 454 186 0.1651 0.1742 0.4097 0.4178
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 475 218 0.1583 0.1742 0.4589 0.4178
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 1 525 202 0.1990 0.1742 0.3848 0.4178
WM-115 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 3 1178 671 0.1556 0.1743 0.5696 0.5669
WM-115 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 2 1376 799 0.1770 0.1743 0.5807 0.5669
WM-115 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 1 1379 759 0.1902 0.1743 0.5504 0.5669
COLO 858 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 1 1836 631 0.2041 0.1780 0.3437 0.3147
COLO 858 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 2 1555 466 0.1845 0.1780 0.2997 0.3147
COLO 858 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 3 1227 369 0.1453 0.1780 0.3007 0.3147
A-375 Vemurafenib I-BET151 0.316 1.000
uM
 72
hr
 1 2938 245 0.1947 0.1801 0.0834 0.0950
MMAC-SF Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 453 159 0.1811 0.1801 0.3510 0.3728
A-375 Vemurafenib I-BET151 0.316 1.000
uM
 72
hr
 2 2781 281 0.1807 0.1801 0.1010 0.0950