Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 1 1635 1328 0.0939 0.0728 0.8122 0.8214
COLO 858 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 3 977 819 0.0483 0.0728 0.8383 0.8214
COLO 858 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 2 1336 1087 0.0761 0.0728 0.8136 0.8214
COLO 858 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 1 1125 559 0.1021 0.0736 0.4969 0.5166
COLO 858 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 3 601 317 0.0512 0.0736 0.5275 0.5166
COLO 858 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 2 788 414 0.0674 0.0736 0.5254 0.5166
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 2 1274 753 0.0744 0.0748 0.5911 0.5989
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 3 1297 782 0.0736 0.0748 0.6029 0.5989
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 1 1347 812 0.0764 0.0748 0.6028 0.5989
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 2 1554 62 0.0781 0.0757 0.0399 0.0403
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 1649 67 0.0828 0.0757 0.0406 0.0403
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 1316 53 0.0661 0.0757 0.0403 0.0403
COLO 858 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 1 1468 1062 0.0932 0.0767 0.7234 0.7291
COLO 858 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 2 1263 917 0.0794 0.0767 0.7260 0.7291
COLO 858 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 3 957 706 0.0576 0.0767 0.7377 0.7291
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 1 972 720 0.0765 0.0787 0.7407 0.7868
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 2 1300 1033 0.0810 0.0787 0.7946 0.7868
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 3 1480 1221 0.0786 0.0787 0.8250 0.7868
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 1 1035 564 0.0849 0.0793 0.5449 0.5384
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 2 956 466 0.0884 0.0793 0.4874 0.5384
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 3 858 500 0.0646 0.0793 0.5828 0.5384
A-375 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 1899 295 0.0769 0.0825 0.1553 0.1694
A-375 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 2204 325 0.0900 0.0825 0.1475 0.1694
A-375 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 1 2119 435 0.0807 0.0825 0.2053 0.1694
COLO 858 Vemurafenib Belinostat 1.000 1.000
uM
 72
hr
 3 1002 665 0.0773 0.0829 0.6637 0.6809