Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib I-BET 1.000 0.000
uM
 72
hr
 3 1357 576 0.2388 0.1880 0.4245 0.4335
COLO 858 Vemurafenib I-BET 1.000 0.000
uM
 72
hr
 2 975 407 0.1736 0.1880 0.4174 0.4335
A-375 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 1 1979 884 0.0774 0.0702 0.4467 0.4350
A-375 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 2 1849 762 0.0769 0.0702 0.4121 0.4350
A-375 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 3 1434 640 0.0562 0.0702 0.4463 0.4350
COLO 858 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 2 904 415 0.1484 0.1822 0.4591 0.4375
COLO 858 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 1 1181 405 0.2356 0.1822 0.3429 0.4375
COLO 858 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 3 1095 559 0.1627 0.1822 0.5105 0.4375
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 2 1366 641 0.1307 0.1377 0.4693 0.4424
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 1510 705 0.1452 0.1377 0.4669 0.4424
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 1 1250 489 0.1372 0.1377 0.3912 0.4424
MMAC-SF Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 591 241 0.2157 0.2403 0.4078 0.4433
MMAC-SF Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 816 378 0.2699 0.2403 0.4632 0.4433
MMAC-SF Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 706 324 0.2354 0.2403 0.4589 0.4433
COLO 858 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 1 1420 605 0.1381 0.1369 0.4261 0.4519
COLO 858 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 3 1647 765 0.1494 0.1369 0.4645 0.4519
COLO 858 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 2 1359 632 0.1232 0.1369 0.4650 0.4519
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 3 1514 710 0.0955 0.1083 0.4690 0.4526
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 2 1784 762 0.1213 0.1083 0.4271 0.4526
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 1692 781 0.1082 0.1083 0.4616 0.4526
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 395 154 0.2440 0.2143 0.3899 0.4559
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 3 366 188 0.1802 0.2143 0.5137 0.4559
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 2 403 187 0.2187 0.2143 0.4640 0.4559
COLO 858 Vemurafenib I-BET 0.316 1.000
uM
 72
hr
 1 1380 561 0.2504 0.2016 0.4065 0.4572
COLO 858 Vemurafenib I-BET 0.316 1.000
uM
 72
hr
 2 1241 591 0.1987 0.2016 0.4762 0.4572