Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 3780 251 0.9177 0.9211 0.0664 0.0646
WM-115 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 3 2813 183 0.7538 0.7662 0.0651 0.0650
WM-115 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 2 2905 193 0.7773 0.7662 0.0664 0.0650
WM-115 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 1 2860 182 0.7676 0.7662 0.0636 0.0650
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 4690 306 0.9633 1.1499 0.0652 0.0651
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 6042 428 1.2336 1.1499 0.0708 0.0651
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 6060 359 1.2527 1.1499 0.0592 0.0651
MMAC-SF Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 2 1093 67 0.8186 0.7894 0.0613 0.0654
MMAC-SF Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 1 984 71 0.7285 0.7894 0.0722 0.0654
MMAC-SF Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 3 1098 69 0.8210 0.7894 0.0628 0.0654
MZ7-mel Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 3491 225 1.0652 1.0000 0.0645 0.0654
A-375 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 5915 430 0.2777 0.2714 0.0727 0.0654
MZ7-mel Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 3299 192 1.0134 1.0000 0.0582 0.0654
MZ7-mel Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 3049 224 0.9214 1.0000 0.0735 0.0654
A-375 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 5334 374 0.2512 0.2714 0.0701 0.0654
A-375 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 5949 318 0.2851 0.2714 0.0535 0.0654
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 3619 242 0.8072 0.8216 0.0669 0.0659
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 3649 235 0.8160 0.8216 0.0644 0.0659
WM-115 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 2904 195 0.7044 0.7665 0.0671 0.0659
WM-115 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 2 3246 205 0.7908 0.7665 0.0632 0.0659
WM-115 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 3 3316 223 0.8043 0.7665 0.0672 0.0659
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 3771 250 0.8416 0.8216 0.0663 0.0659
MZ7-mel Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 2847 207 0.5309 0.4729 0.0727 0.0666
MZ7-mel Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 2 2815 143 0.5373 0.4729 0.0508 0.0666
MZ7-mel Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 1886 144 0.3503 0.4729 0.0764 0.0666