Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 19375 946 1.0025 1.0000 0.0488 0.0485
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 1 19613 936 1.0160 1.0000 0.0477 0.0485
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 2 1126 71 0.8418 0.7976 0.0631 0.0486
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 1047 45 0.7995 0.7976 0.0430 0.0486
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 981 39 0.7516 0.7976 0.0398 0.0486
A-375 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 1 1292 66 0.0621 0.0577 0.0511 0.0487
MMAC-SF Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 901 34 0.6918 0.6184 0.0377 0.0487
MMAC-SF Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 630 33 0.4763 0.6184 0.0524 0.0487
MMAC-SF Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 2 912 51 0.6870 0.6184 0.0559 0.0487
A-375 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 3 1130 64 0.0540 0.0577 0.0566 0.0487
A-375 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 2 1173 45 0.0571 0.0577 0.0384 0.0487
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 591 30 0.5509 0.7915 0.0508 0.0491
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 854 49 0.7905 0.7915 0.0574 0.0491
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 1095 43 1.0331 0.7915 0.0393 0.0491
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 5745 285 0.3434 0.2974 0.0496 0.0491
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 5681 246 0.3419 0.2974 0.0433 0.0491
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 3476 189 0.2068 0.2974 0.0544 0.0491
MMAC-SF Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 2 755 33 0.7090 0.7182 0.0437 0.0494
MMAC-SF Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 3 563 36 0.5175 0.7182 0.0639 0.0494
MMAC-SF Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 1 985 40 0.9280 0.7182 0.0406 0.0494
WM-115 Vemurafenib I-BET 0.100 0.000
uM
 72
hr
 3 3445 152 0.9446 0.9015 0.0441 0.0495
WM-115 Vemurafenib I-BET 0.100 0.000
uM
 72
hr
 2 3375 186 0.9148 0.9015 0.0551 0.0495
WM-115 Vemurafenib I-BET 0.100 0.000
uM
 72
hr
 1 3099 153 0.8451 0.9015 0.0494 0.0495
MMAC-SF Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 1 933 49 0.8681 0.6959 0.0525 0.0496
MMAC-SF Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 2 757 37 0.7070 0.6959 0.0489 0.0496