Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 1489 75 0.4483 0.9268 0.0504 0.0478
MZ7-mel Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 3244 144 0.9829 0.9268 0.0444 0.0478
MZ7-mel Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 4472 217 1.3491 0.9268 0.0485 0.0478
MZ7-mel Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 2653 123 0.7299 0.6853 0.0464 0.0479
MZ7-mel Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 3 2777 121 0.7662 0.6853 0.0436 0.0479
MZ7-mel Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 1 2050 110 0.5597 0.6853 0.0537 0.0479
A-375 Vemurafenib I-BET151 0.100 1.000
uM
 72
hr
 2 4119 181 0.2846 0.2971 0.0439 0.0480
A-375 Vemurafenib I-BET151 0.100 1.000
uM
 72
hr
 1 4645 211 0.3205 0.2971 0.0454 0.0480
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 1 736 41 0.7037 0.8032 0.0557 0.0480
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 894 41 0.8637 0.8032 0.0459 0.0480
A-375 Vemurafenib I-BET151 0.100 1.000
uM
 72
hr
 3 4187 229 0.2861 0.2971 0.0547 0.0480
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 3 869 37 0.8424 0.8032 0.0426 0.0480
A-375 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 3 2509 127 0.1296 0.1363 0.0506 0.0481
A-375 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 2 2552 108 0.1329 0.1363 0.0423 0.0481
A-375 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 1 2836 146 0.1463 0.1363 0.0515 0.0481
MZ7-mel Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 1 1692 86 0.3230 0.2758 0.0508 0.0483
MZ7-mel Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 2 1482 62 0.2856 0.2758 0.0418 0.0483
MZ7-mel Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 3 1148 60 0.2188 0.2758 0.0523 0.0483
A-375 Vemurafenib I-BET 0.100 1.000
uM
 72
hr
 3 3934 188 0.2747 0.3080 0.0478 0.0484
A-375 Vemurafenib I-BET 0.100 1.000
uM
 72
hr
 2 4395 227 0.3057 0.3080 0.0516 0.0484
A-375 Vemurafenib I-BET 0.100 1.000
uM
 72
hr
 1 4909 225 0.3435 0.3080 0.0458 0.0484
MZ7-mel Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 2714 123 0.8451 0.7294 0.0453 0.0484
MZ7-mel Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 1917 95 0.5943 0.7294 0.0496 0.0484
MZ7-mel Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 2 2418 122 0.7489 0.7294 0.0505 0.0484
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 18973 930 0.9815 1.0000 0.0490 0.0485