Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 1995 254 0.4161 0.4208 0.1273 0.1284
WM-115 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 1905 223 0.4020 0.4208 0.1171 0.1284
WM-115 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 1 2164 305 0.4443 0.4208 0.1409 0.1284
WM-115 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 1 2506 243 0.5885 0.5553 0.0970 0.0985
WM-115 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 2 2322 246 0.5398 0.5553 0.1059 0.0985
WM-115 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 3 2278 211 0.5375 0.5553 0.0926 0.0985
WM-115 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 2173 305 0.4857 0.4743 0.1404 0.1338
WM-115 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 2 2061 274 0.4647 0.4743 0.1329 0.1338
WM-115 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 2084 267 0.4725 0.4743 0.1281 0.1338
WM-115 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 1912 153 0.4204 0.4405 0.0800 0.0768
WM-115 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 1877 148 0.4133 0.4405 0.0788 0.0768
WM-115 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 2198 157 0.4878 0.4405 0.0714 0.0768
A-375 Vemurafenib JNK-IN-8 0.316 3.160
uM
 72
hr
 3 1928 244 0.1059 0.1134 0.1266 0.1152
A-375 Vemurafenib JNK-IN-8 0.316 3.160
uM
 72
hr
 2 2210 240 0.1239 0.1134 0.1086 0.1152
A-375 Vemurafenib JNK-IN-8 0.316 3.160
uM
 72
hr
 1 1972 218 0.1103 0.1134 0.1105 0.1152
WM-115 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 1 1760 362 0.3635 0.3608 0.2057 0.1852
WM-115 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 2 1740 336 0.3651 0.3608 0.1931 0.1852
WM-115 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 3 1614 253 0.3539 0.3608 0.1568 0.1852
WM-115 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 1 1354 459 0.2327 0.2251 0.3390 0.3147
WM-115 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 1196 350 0.2200 0.2251 0.2926 0.3147
WM-115 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 3 1245 389 0.2226 0.2251 0.3124 0.3147
WM-115 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 941 527 0.1033 0.1103 0.5600 0.5337
WM-115 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 975 559 0.1038 0.1103 0.5733 0.5337
WM-115 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 930 435 0.1236 0.1103 0.4677 0.5337
MMAC-SF Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 1 1338 86 0.9589 0.7322 0.0643 0.0524