Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 2 5304 139 0.2615 0.2652 0.0262 0.0225
A-375 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 7790 111 0.3888 0.4180 0.0142 0.0173
A-375 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 5737 112 0.2848 0.2652 0.0195 0.0225
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 20251 1109 1.0021 1.0000 0.0548 0.0527
A-375 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 2 8744 163 0.4345 0.4180 0.0186 0.0173
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 3779 175 0.1727 0.1741 0.0463 0.0433
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 7818 140 0.4019 0.4364 0.0179 0.0207
A-375 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 7190 141 0.4434 0.4477 0.0196 0.0178
A-375 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 8666 164 0.4305 0.4180 0.0189 0.0173
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 22233 990 1.0180 1.0000 0.0445 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 20940 1098 1.0048 1.0000 0.0524 0.0504
A-375 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 2887 241 0.1268 0.1293 0.0835 0.0864
A-375 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 1 7134 125 0.4409 0.4477 0.0175 0.0178
A-375 Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 3 4768 111 0.2929 0.2659 0.0233 0.0217
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 3676 151 0.1689 0.1741 0.0411 0.0433
A-375 Vemurafenib JNK-IN-8 1.000 0.000
uM
 72
hr
 2 3545 130 0.2148 0.2091 0.0367 0.0362
A-375 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 2 3957 137 0.1934 0.1953 0.0346 0.0349
A-375 Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 1 2723 183 0.1598 0.1658 0.0672 0.0732
A-375 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 2966 270 0.1292 0.1293 0.0910 0.0864
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 13441 248 0.6323 0.4565 0.0185 0.0200
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 8056 164 0.3782 0.4565 0.0204 0.0200
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 3 2950 229 0.1424 0.1538 0.0776 0.0753
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 2 3197 255 0.1540 0.1538 0.0798 0.0753