Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 3017 261 0.6588 0.6656 0.0865 0.0837
WM-115 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 2 2188 416 0.5437 0.4990 0.1901 0.1975
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 1 1748 230 0.2738 0.2879 0.1316 0.1549
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 2 1817 313 0.2712 0.2879 0.1723 0.1549
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 3 2106 339 0.3187 0.2879 0.1610 0.1549
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 2 8079 212 0.4118 0.4364 0.0262 0.0207
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 950 43 0.8907 0.8036 0.0453 0.0497
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 7818 140 0.4019 0.4364 0.0179 0.0207
WM-115 Vemurafenib Belinostat 0.100 0.000
uM
 72
hr
 3 3136 146 0.8573 0.8519 0.0466 0.0498
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 20940 1098 1.0048 1.0000 0.0524 0.0504
COLO 858 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 1 1042 801 0.0435 0.0334 0.7687 0.8371
WM-115 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 2072 591 0.3540 0.3601 0.2852 0.2576
COLO 858 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 3 1251 1101 0.0271 0.0334 0.8801 0.8371
COLO 858 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 2 1199 1034 0.0298 0.0334 0.8624 0.8371
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 1 1250 489 0.1372 0.1377 0.3912 0.4424
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 2 1366 641 0.1307 0.1377 0.4693 0.4424
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 1510 705 0.1452 0.1377 0.4669 0.4424
WM-115 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 2066 489 0.3769 0.3601 0.2367 0.2576
MMAC-SF Vemurafenib JNK-IN-8 1.000 0.000
uM
 72
hr
 3 900 279 0.6098 0.5178 0.3100 0.3105
WM-115 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 2465 330 0.5103 0.5412 0.1339 0.1460
MMAC-SF Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 2 492 180 0.3064 0.3466 0.3659 0.3504
WM-115 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 1950 489 0.3492 0.3601 0.2508 0.2576
WM-115 Vemurafenib Belinostat 3.160 0.000
uM
 72
hr
 3 1968 434 0.4398 0.4271 0.2205 0.2254
WM-115 Vemurafenib Belinostat 3.160 0.000
uM
 72
hr
 2 1953 461 0.4278 0.4271 0.2360 0.2254