Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 1 3640 140 0.1832 0.1915 0.0385 0.0418
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 2 3900 189 0.1943 0.1915 0.0485 0.0418
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 3 3917 151 0.1971 0.1915 0.0385 0.0418
COLO 858 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 1 3373 297 0.5101 0.4962 0.0881 0.0847
WM-115 Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 3017 261 0.6588 0.6656 0.0865 0.0837
WM-115 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 2 2788 413 0.5677 0.5412 0.1481 0.1460
WM-115 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 2465 330 0.5103 0.5412 0.1339 0.1460
COLO 858 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 3226 262 0.4915 0.4962 0.0812 0.0847
COLO 858 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 2 3208 272 0.4869 0.4962 0.0848 0.0847
COLO 858 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 3752 367 0.4835 0.4885 0.0978 0.0896
COLO 858 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 2 3991 355 0.5194 0.4885 0.0890 0.0896
COLO 858 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 2 2562 425 0.3053 0.3034 0.1659 0.1673
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 1 3381 232 0.1648 0.1538 0.0686 0.0753
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 2 3197 255 0.1540 0.1538 0.0798 0.0753
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 3 2950 229 0.1424 0.1538 0.0776 0.0753
A-375 Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 2 4429 94 0.2727 0.2659 0.0212 0.0217
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 13441 248 0.6323 0.4565 0.0185 0.0200
A-375 Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 3 4768 111 0.2929 0.2659 0.0233 0.0217
COLO 858 Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 2 1051 926 0.0207 0.0290 0.8811 0.8526
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 8056 164 0.3782 0.4565 0.0204 0.0200
COLO 858 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 1 2454 395 0.2941 0.3034 0.1610 0.1673
A-375 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 1 3774 124 0.1848 0.1953 0.0329 0.0349
COLO 858 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 2637 462 0.3107 0.3034 0.1752 0.1673
MMAC-SF Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 3 756 273 0.3854 0.3431 0.3611 0.3687
MMAC-SF Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 2 642 245 0.3168 0.3431 0.3816 0.3687