Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 5915 430 0.2777 0.2714 0.0727 0.0654
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 9020 322 0.4553 0.4801 0.0357 0.0412
A-375 Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 1 9132 411 0.4565 0.3648 0.0450 0.0413
A-375 Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 2 6541 255 0.3291 0.3648 0.0390 0.0413
A-375 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 1 3016 167 0.1443 0.1539 0.0554 0.0544
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 7914 1171 0.9632 1.0000 0.1480 0.1514
COLO 858 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 2337 557 0.2543 0.2671 0.2383 0.2394
COLO 858 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 2951 631 0.3314 0.2671 0.2138 0.2394
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 19971 929 0.9642 1.0000 0.0465 0.0504
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 22233 990 1.0180 1.0000 0.0445 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 18341 936 0.8341 0.8197 0.0510 0.0506
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 18747 969 0.8520 0.8197 0.0517 0.0506
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 9567 390 0.4398 0.4342 0.0408 0.0408
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 2 10229 430 0.4696 0.4342 0.0420 0.0408
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 3 8546 338 0.3934 0.4342 0.0396 0.0408
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 2168 298 0.0896 0.0889 0.1375 0.1262
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 2198 268 0.0925 0.0889 0.1219 0.1262
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 2006 239 0.0847 0.0889 0.1191 0.1262
A-375 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 3 3339 171 0.1604 0.1539 0.0512 0.0544
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 11246 370 0.6841 0.6866 0.0329 0.0312
COLO 858 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 9513 1495 0.9520 1.0000 0.1572 0.1501
COLO 858 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 10083 1500 1.0190 1.0000 0.1488 0.1501