Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 3 6145 245 0.3089 0.3648 0.0399 0.0413
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 17737 603 1.0777 1.0016 0.0340 0.0383
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 11677 368 0.7113 0.6866 0.0315 0.0312
WM-115 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 3709 210 0.8363 0.8635 0.0566 0.0685
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 2 10880 316 0.6645 0.6866 0.0290 0.0312
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 11246 370 0.6841 0.6866 0.0329 0.0312
COLO 858 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 6029 760 0.9502 1.0000 0.1261 0.1418
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 5745 285 0.3434 0.2974 0.0496 0.0491
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 18341 936 0.8341 0.8197 0.0510 0.0506
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 5681 246 0.3419 0.2974 0.0433 0.0491
WM-115 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 1877 148 0.4133 0.4405 0.0788 0.0768
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 3476 189 0.2068 0.2974 0.0544 0.0491
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 20940 1098 1.0048 1.0000 0.0524 0.0504
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 18747 969 0.8520 0.8197 0.0517 0.0506
COLO 858 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 6456 909 1.0004 1.0000 0.1408 0.1418
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 9567 390 0.4398 0.4342 0.0408 0.0408
COLO 858 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 4700 704 0.4744 0.5301 0.1498 0.1528
WM-115 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 3870 269 0.9108 0.9197 0.0695 0.0725
WM-115 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 3981 292 0.9331 0.9197 0.0733 0.0725
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 2 10229 430 0.4696 0.4342 0.0420 0.0408
COLO 858 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 1 5564 919 0.8377 0.9265 0.1652 0.1634
A-375 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 5949 318 0.2851 0.2714 0.0535 0.0654
MZ7-mel Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 3244 144 0.9829 0.9268 0.0444 0.0478
MZ7-mel Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 4472 217 1.3491 0.9268 0.0485 0.0478