Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 2302 149 0.4731 0.3676 0.0647 0.0695
A-375 Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 1 3804 246 0.2238 0.1826 0.0647 0.0764
A-375 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 1 1388 90 0.0657 0.0636 0.0648 0.0545
MZ7-mel Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 1755 114 0.3300 0.3530 0.0650 0.0606
WM-115 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 3 2813 183 0.7538 0.7662 0.0651 0.0650
MZ7-mel Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 1 1274 83 0.3885 0.4386 0.0651 0.0724
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 4690 306 0.9633 1.1499 0.0652 0.0651
A-375 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 1 2147 140 0.1092 0.0988 0.0652 0.0671
MZ7-mel Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 2 2102 137 0.3952 0.3781 0.0652 0.0626
WM-115 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 2 2651 173 0.6444 0.6617 0.0653 0.0684
MZ7-mel Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 3 1210 79 0.2274 0.3143 0.0653 0.0600
MZ7-mel Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 1 2062 135 0.6285 0.4197 0.0655 0.0627
MMAC-SF Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 1 1049 69 0.7506 0.6857 0.0658 0.0645
MZ7-mel Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 2 2481 164 0.4659 0.4188 0.0661 0.0678
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 3771 250 0.8416 0.8216 0.0663 0.0659
WM-115 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 3558 236 0.8638 0.8606 0.0663 0.0629
A-375 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 2 3221 214 0.1523 0.1621 0.0664 0.0672
WM-115 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 3780 251 0.9177 0.9211 0.0664 0.0646
WM-115 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 2 2905 193 0.7773 0.7662 0.0664 0.0650
WM-115 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 3738 249 0.8709 0.8638 0.0666 0.0643
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 3619 242 0.8072 0.8216 0.0669 0.0659
WM-115 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 3214 215 0.7168 0.6669 0.0669 0.0743
MZ7-mel Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 2225 149 0.4562 0.4826 0.0670 0.0734
WM-115 Vemurafenib Belinostat 0.316 0.000
uM
 72
hr
 3 2658 178 0.7111 0.7002 0.0670 0.0767
WM-115 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 2904 195 0.7044 0.7665 0.0671 0.0659