Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 1 1462 72 0.4407 0.5486 0.0492 0.0710
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
MZ7-mel Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 3308 163 0.6325 0.5541 0.0493 0.0507
MMAC-SF Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 1401 69 1.0202 1.0000 0.0493 0.0520
MZ7-mel Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 2941 145 0.8865 0.7710 0.0493 0.0544
A-375 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 3 3001 148 0.2018 0.1959 0.0493 0.0416
WM-115 Vemurafenib I-BET 0.100 0.000
uM
 72
hr
 1 3099 153 0.8451 0.9015 0.0494 0.0495
A-375 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 2 16317 808 0.9755 1.0000 0.0495 0.0476
WM-115 Vemurafenib Belinostat 0.000 1.000
uM
 72
hr
 1 2039 101 0.5557 0.4993 0.0495 0.0637
MMAC-SF Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 1351 67 0.9834 1.0000 0.0496 0.0520
MZ7-mel Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 1917 95 0.5943 0.7294 0.0496 0.0484
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 5745 285 0.3434 0.2974 0.0496 0.0491
WM-115 Vemurafenib I-BET151 0.100 0.000
uM
 72
hr
 2 3303 164 0.8997 0.9074 0.0497 0.0514
MZ7-mel Vemurafenib PF562271 0.100 1.000
uM
 72
hr
 1 2768 138 0.7587 0.6073 0.0499 0.0523
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 2 18224 910 0.9418 0.8926 0.0499 0.0523
A-375 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 1 2938 147 0.1338 0.1394 0.0500 0.0554
MMAC-SF Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 2119 106 1.2403 1.1047 0.0500 0.0462
MMAC-SF Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 1040 52 0.7567 0.7202 0.0500 0.0513
MZ7-mel Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 1 2852 143 0.7815 0.9528 0.0501 0.0436
MZ7-mel Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 1 2113 106 0.5790 0.4111 0.0502 0.0604
MZ7-mel Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 3 3728 187 0.7781 0.7316 0.0502 0.0510
MMAC-SF Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 3 1432 72 1.3770 1.2926 0.0503 0.0509
MMAC-SF Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 915 46 0.6656 0.7554 0.0503 0.0454
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 9957 502 0.4950 0.4801 0.0504 0.0412
MZ7-mel Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 2 3036 153 0.9141 0.8443 0.0504 0.0545