Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 2 1106 50 0.8088 0.7554 0.0452 0.0454
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 14559 660 0.7276 0.7489 0.0453 0.0459
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 950 43 0.8907 0.8036 0.0453 0.0497
MZ7-mel Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 2 1676 76 0.5219 0.5199 0.0453 0.0507
MZ7-mel Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 2714 123 0.8451 0.7294 0.0453 0.0484
A-375 Vemurafenib I-BET151 0.100 1.000
uM
 72
hr
 1 4645 211 0.3205 0.2971 0.0454 0.0480
MMAC-SF Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 1620 74 0.9526 1.0000 0.0457 0.0422
A-375 Vemurafenib I-BET 0.100 1.000
uM
 72
hr
 1 4909 225 0.3435 0.3080 0.0458 0.0484
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 1 721 33 0.6756 0.8036 0.0458 0.0497
MMAC-SF Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 3 653 30 0.4772 0.6038 0.0459 0.0460
MMAC-SF Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 1504 69 1.1449 1.0000 0.0459 0.0496
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 894 41 0.8637 0.8032 0.0459 0.0480
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 3779 175 0.1727 0.1741 0.0463 0.0433
A-375 Vemurafenib Belinostat 0.000 0.000
uM
 72
hr
 3 14239 660 1.0368 1.0000 0.0464 0.0803
MZ7-mel Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 2653 123 0.7299 0.6853 0.0464 0.0479
A-375 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 3 1204 56 0.0581 0.0636 0.0465 0.0545
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 19971 929 0.9642 1.0000 0.0465 0.0504
WM-115 Vemurafenib Belinostat 0.100 0.000
uM
 72
hr
 3 3136 146 0.8573 0.8519 0.0466 0.0498
WM-115 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 2 3366 157 0.9846 1.0000 0.0466 0.0538
MMAC-SF Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 3 451 21 0.4354 0.6021 0.0466 0.0426
WM-115 Vemurafenib Belinostat 0.000 0.000
uM
 72
hr
 1 3852 180 1.0529 1.0000 0.0467 0.0525
A-375 Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 3 8504 397 0.4410 0.4696 0.0467 0.0532
A-375 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 1 1112 52 0.0537 0.0545 0.0468 0.0467
WM-115 Vemurafenib Belinostat 0.100 0.000
uM
 72
hr
 1 3106 146 0.8487 0.8519 0.0470 0.0498
WM-115 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 3766 177 0.9702 1.0000 0.0470 0.0560