Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 3787 264 0.9161 0.9211 0.0697 0.0646
A-375 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 2 3786 100 0.2005 0.1991 0.0264 0.0233
COLO 858 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 3782 731 0.5059 0.4677 0.1933 0.1974
WM-115 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 3780 251 0.9177 0.9211 0.0664 0.0646
A-375 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 3779 175 0.1727 0.1741 0.0463 0.0433
MZ7-mel Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 2 3775 147 1.0466 0.9528 0.0389 0.0436
A-375 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 1 3774 124 0.1848 0.1953 0.0329 0.0349
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 3771 250 0.8416 0.8216 0.0663 0.0659
A-375 Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 1 3770 78 0.2322 0.2659 0.0207 0.0217
WM-115 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 3766 177 0.9702 1.0000 0.0470 0.0560
WM-115 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 3766 260 0.8868 0.8594 0.0690 0.0671
COLO 858 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 3752 367 0.4835 0.4885 0.0978 0.0896
WM-115 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 3744 263 0.8804 0.8272 0.0702 0.0678
COLO 858 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 3740 546 0.5411 0.5771 0.1460 0.1387
WM-115 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 3738 249 0.8709 0.8638 0.0666 0.0643
MZ7-mel Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 3736 214 1.0161 1.0000 0.0573 0.0545
MZ7-mel Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 3734 195 1.0210 1.0000 0.0522 0.0545
A-375 Vemurafenib Belinostat 0.316 0.000
uM
 72
hr
 2 3734 151 0.2736 0.2662 0.0404 0.0401
WM-115 Vemurafenib I-BET 0.000 0.000
uM
 72
hr
 3 3731 209 1.0103 1.0000 0.0560 0.0556
MZ7-mel Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 3 3728 187 0.7781 0.7316 0.0502 0.0510
MZ7-mel Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 3 3726 155 1.0302 0.9528 0.0416 0.0436
COLO 858 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 3 3719 340 0.5724 0.3290 0.0914 0.2076
WM-115 Vemurafenib I-BET 0.000 0.000
uM
 72
hr
 2 3715 220 1.0026 1.0000 0.0592 0.0556
A-375 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 3713 167 0.1929 0.1949 0.0450 0.0429
WM-115 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 3709 210 0.8363 0.8635 0.0566 0.0685