Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 1 1706 704 0.1431 0.1375 0.4127 0.4603
COLO 858 Vemurafenib JNK-IN-8 1.000 0.316
uM
 72
hr
 3 1101 702 0.0662 0.0722 0.6376 0.5757
COLO 858 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 2 5229 702 0.7507 0.7398 0.1343 0.1305
COLO 858 Vemurafenib I-BET151 0.316 1.000
uM
 72
hr
 2 1178 702 0.1100 0.1085 0.5959 0.5981
COLO 858 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 3 1602 701 0.2735 0.2031 0.4376 0.4582
WM-115 Vemurafenib (+)-JQ1 3.160 1.000
uM
 72
hr
 2 1263 699 0.1730 0.1677 0.5534 0.5580
COLO 858 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 3469 698 0.4595 0.4677 0.2012 0.1974
COLO 858 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 1178 697 0.0571 0.0598 0.5917 0.6178
COLO 858 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 5271 697 0.7585 0.7398 0.1322 0.1305
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 726 696 0.0051 0.0054 0.9587 0.9547
WM-115 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 2 1659 693 0.2769 0.2677 0.4177 0.4255
COLO 858 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 3 790 691 0.0179 0.0248 0.8747 0.8407
COLO 858 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 3 810 688 0.0207 0.0199 0.8494 0.8770
COLO 858 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 2 833 687 0.0263 0.0248 0.8247 0.8407
WM-115 Vemurafenib I-BET 1.000 1.000
uM
 72
hr
 3 1611 687 0.2651 0.3008 0.4264 0.4036
A-375 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 1 2097 686 0.1020 0.0884 0.3271 0.3475
COLO 858 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 2 1227 686 0.0773 0.0722 0.5591 0.5817
COLO 858 Vemurafenib JNK-IN-8 0.316 3.160
uM
 72
hr
 1 1246 683 0.0934 0.0962 0.5482 0.5276
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 2 736 681 0.0093 0.0093 0.9253 0.9244
MZ7-mel Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 1988 681 0.2872 0.2848 0.3426 0.3145
WM-115 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 1 1897 677 0.3045 0.2911 0.3569 0.3460
COLO 858 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 1051 677 0.0634 0.0618 0.6441 0.6473
WM-115 Vemurafenib JNK-IN-8 1.000 3.160
uM
 72
hr
 1 1801 675 0.2848 0.2705 0.3748 0.4169
COLO 858 Vemurafenib Belinostat 0.316 1.000
uM
 72
hr
 1 1176 674 0.1152 0.1069 0.5731 0.5774
COLO 858 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 2 921 673 0.0447 0.0514 0.7307 0.7028